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Details for messenger / hormone: PTHLH

EndoNet ID: ENH00222

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Synonyms

  • PTHrP[107-139]
  • parathyroid hormone-like protein
  • PTHLH
  • PTH-rP
  • PTHrP
  • parathyroid hormone-related peptide
  • parathyroid hormone-like hormone
  • PTHR
  • parathyroid hormone-related protein

General information

  • PTHrp is synthesized in various tissues including keratinocytes, lactating mammary tissue, the placenta and fetal parathyroid glands and has actions similar to PTH. [1]
  • The cancer modifier effects of the mouse Pthlh (parathyroid hormone-like hormone) gene are mediated by differential cell adhesion and migration effects of PTHrP variants. [2]

Classification

Hormone function

  • development and growth
    • embryogenesis

    Chemical classification

    • hormone
      • genome-encoded
        • parathyroid hormone family

      Composition

      PTHrP[1-36]

      Sequence
      AVSEHQLLH DKGKSIQDL RRRFFLHHL 
      IAEIHTAEI

      PTHrP[38-94]

      Sequence
      ATSEVSPNS KPSPNTKNH PVRFGSDDE 
      GRYLTQETN KVETYKEQP LKTPGKKKK 
      GKP

      parathyroid hormone-related protein

      Sequence
      AVSEHQLLH DKGKSIQDL RRRFFLHHL 
      IAEIHTAEI RATSEVSPN SKPSPNTKN 
      HPVRFGSDD EGRYLTQET NKVETYKEQ 
      PLKTPGKKK KGKPGKRKE QEKKKRRTR 
      SAWLDSGVT GSGLEGDHL SDTSTTSLE 
      LDSRRH

      osteostatin

      Sequence
      TRSAWLDSG VTGSGLEGD HLSDTSTTS 
      LELDSR

      Links to other resources

      UniProt P12272
      Ensembl ENST00000395872
      KEGG hsa:5744
      • Anatomical structure: keratinocyte

      • Anatomical structure: placenta

      • Anatomical structure: fibroblast

      • Anatomical structure: mammary_gland

        Influenced by:

        • CaSR
          in mammary_gland
          • The calcium-sensing receptor (CaR) is a G-protein-coupled receptor that signals in response to extracellular calcium and regulates parathyroid hormone secretion. The CaR is also expressed on normal mammary epithelial cells (MMECs), where it has been shown to inhibit secretion of parathyroid hormone-related protein (PTHrP) and participate in the regulation of calcium and bone metabolism during lactation. [3]

      Targets

      CellPTHR1
      chondrocyte Present
      hematopoietic stem cell Present
      Influences
      • RANKL
      kidney Present
      Phenotypes
      • phosphate ion homeostasis
      • familial isolated hypoparathyroidism
      • Primary hyperparathyroidism
      Influences
      • calcitriol
      osteoblast Present
      Influences
      • RANKL
      • M-CSF
      • interleukin 6
      • amphiregulin
      osteoclast Present
      stromal cell of bone marrow Present
      Influences
      • RANKL
      • M-CSF
      Reference