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Details for messenger / hormone: TGF-beta 3

EndoNet ID: ENH00223

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Synonyms

  • transforming growth factor beta-3
  • TGF-beta 3
  • transforming growth factor beta 3

General information

  • Involved in embryogenesis and cell differentiation. [1]
  • TGF-beta-mediated epithelial-mesenchymal transition of mammary epithelial cells is accompagnied by the loss of laminin-5 production and the upregulation of fibronectin and its alpha-5/beta-1 integrin receptor. [2]

Classification

Hormone function

  • development and growth
    • embryogenesis
      • environment adaptation

      Chemical classification

      • hormone
        • genome-encoded
          • cytokines
            • TGF-beta family

        Composition

        Sequence
        ALDTNYCFR NLEENCCVR PLYIDFRQD 
        LGWKWVHEP KGYYANFCS GPCPYLRSA 
        DTTHSTVLG LYNTLNPEA SASPCCVPQ 
        DLEPLTILY YVGRTPKVE QLSNMVVKS 
        CKCS

        Links to other resources

        UniProt P10600
        Ensembl ENST00000238682
        KEGG hsa:7043
        • Anatomical structure: osteoblast

          • Osteoblasts expresses mRNA transcripts of TGF-beta1, TGF-beta2, TGF-beta 3, TGF-beta type I and type II receptors. [3]
        • Anatomical structure: cell_of_endometrium_of_uterus

          • In women, expression of TGF-b1, -b2 and -b3 and the type II receptor occurs in all cell types of the endometrium. [4]
        • Anatomical structure: adrenal_gland

          • TGF-β isoforms 3 is synthesized by cells in the wall of the dorsal aorta as well as at later stages in both cortical and migrating chromaffin cells within the developing adrenal gland. [5]

        Targets

        CellTGF-beta type II receptorvasorin
        adrenal cortex Present
        aorta Present
        brain Present
        cell of endometrium of uterus Present
        Influences
        • TGF-beta 1
        • LIF
        • interleukin 6
        dendritic cell in lymphoid tissues follicular Present
        heart Present
        kidney Present
        lung Present
        mammary gland Present
        osteoblast Present
        placenta Present
        Present
        skeleton muscle Present
        smooth muscle cell Present
        Phenotypes
        • negative regulation of transforming growth factor beta receptor signaling pathway
        Influences
        • TGF-beta 1
        umbilical cord Present
        umbilical vein Present
        umbilical vein endothelial cells Present
        Reference