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Details for messenger / hormone: TGF-beta 4

EndoNet ID: ENH00224

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Synonyms

  • transforming growth factor beta-4
  • protein lefty-A
  • protein lefty-2
  • left-right determination factor 2
  • TGF-beta 4
  • transforming growth factor beta 4
  • endometrial bleeding-associated factor
  • left-right determination factor A
  • lefty-A protein
  • EBAF

General information

  • Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding. [1]
  • TGF-beta-mediated epithelial-mesenchymal transition of mammary epithelial cells is accompagnied by the loss of laminin-5 production and the upregulation of fibronectin and its alpha-5/beta-1 integrin receptor. [2]
  • Inhibits the Nodal signal transduction by binding to the Nodal coreceptors EGF-CFCs as well as to the Nodal ligands. [3]

Classification

Hormone function

  • development and growth
    • embryogenesis

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • TGF-beta family

      Composition

      Sequence 
      RFSQSFREV AGRFLASEA STHLLVFGM 
EQRLPPNSE LVQAVLRLF QEPVPKAAL 
HRHGRLSPR SAQARVTVE WLRVRDDGS 
NRTSLIDSR LVSVHESGW KAFDVTEAV 
NFWQQLSRP RQPLLLQVS VQREHLGPL 
ASGAHKLVR FASQGAPAG LGEPQLELH 
TLDLRDYGA QGDCDPEAP MTEGTRCCR 
QEMYIDLQG MKWAKNWVL EPPGFLAYE 
CVGTCQQPP EALAFNWPF LGPRQCIAS 
ETASLPMIV SIKEGGRTR PQVVSLPNM 
RVQKCSCAS DGALVPRRL QP

      Links to other resources

      UniProt O00292
      Ensembl ENST00000366820
      KEGG hsa:7044

      • Anatomical structure: cell_of_endometrium_of_uterus

        • Expression:Mesenchymal cells of the endometrial stroma. Transiently expressed before and during menstrual bleeding. [1]

      Targets

      Cell
      No records found.
      Reference