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Details for messenger / hormone: FGF-23

EndoNet ID: ENH00227

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Synonyms

  • Phosphatonin
  • FGF-23
  • FGF23
  • fibroblast growth factor 23
  • tumor-derived hypophosphatemia-inducing factor
  • FGFN

General information

  • Serum FGF-23 is increased by calcitriol. [1]
  • FGF-23 regulates serum phosphate and 1,25-dihydroxyvitamin D levels. [2]
  • FGF-23 increases urinary and renal tubular prostaglandin E2 production via the MAP kinase pathway and prostaglandin E2 inhibits proximal tubule phosphate transport. [3]
  • Regulates phosphate homeostasis.
  • FGF-23 is involved in the regulation of phosphate and vitamin D metabolism. [1]

Classification

Hormone function

  • homeostasis
    • ion flow control

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • heparin-binding growth factors

      Composition

      Sequence 
      YPNASPLLG SSWGGLIHL YTATARNSY 
HLQIHKNGH VDGAPHQTI YSALMIRSE 
DAGFVVITG VMSRRYLCM DFRGNIFGS 
HYFDPENCR FQHQTLENG YDVYHSPQY 
HFLVSLGRA KRAFLPGMN PPPYSQFLS 
RRNEIPLIH FNTPIPRRH TRSAEDDSE 
RDPLNVLKP RARMTPAPA SCSQELPSA 
EDNSPMASD PLGVVRGGR VNTHAGGTG 
PEGCRPFAK FI

      Links to other resources

      UniProt Q9GZV9
      Ensembl ENST00000237837
      KEGG hsa:8074

      • Anatomical structure: thymus

      • Anatomical structure: bone

        • FGF23 mRNA expression is found to be highest in bone in both the human and the mouse. [4]

        Influenced by:

        • VDR
          in bone
          • The bone, likely the osteoblast or its precursor cell, is a major source of FGF23 in response to 1alpha,25-Dihydroxyvitamin D3. [4]
          • This establishes a reciprocal relationship between 1,25(OH)2D3 and FGF23, with phosphatemic 1,25(OH)2D3 hormone generated in the kidney, inducing skeletal endocrine cells to produce FGF23, which then feedback represses renal 1alpha-OHase to curtail 1,25(OH)2D3 biosynthesis as well as inhibits the renal reabsorption of phosphate to elicit phosphaturia. [4]
          • 1,25(OH)2D3-induced FGF23 from bone constitutes the final link in a renal-gastrointestinal-skeletal axis that controls serum phosphate and active vitamin D levels. [4]
        • VDR
          in osteoblast
          • The bone, likely the osteoblast or its precursor cell, is a major source of FGF23 in response to 1alpha,25-Dihydroxyvitamin D3. [4]
          • This establishes a reciprocal relationship between 1,25(OH)2D3 and FGF23, with phosphatemic 1,25(OH)2D3 hormone generated in the kidney, inducing skeletal endocrine cells to produce FGF23, which then feedback represses renal 1alpha-OHase to curtail 1,25(OH)2D3 biosynthesis as well as inhibits the renal reabsorption of phosphate to elicit phosphaturia. [4]
          • 1,25(OH)2D3-induced FGF23 from bone constitutes the final link in a renal-gastrointestinal-skeletal axis that controls serum phosphate and active vitamin D levels. [4]

      • Anatomical structure: small_intestine

      • Anatomical structure: heart

      • Anatomical structure: lung

      • Anatomical structure: liver

      • Anatomical structure: kidney

      • Anatomical structure: parathyroid_gland

      • Anatomical structure: lymph_node

      • Anatomical structure: skeleton_muscle

      • Anatomical structure: spleen

      • Anatomical structure: skin

      • Anatomical structure: stomach

      • Anatomical structure: testis

      • Anatomical structure: paraventricular_nucleus_of_hypothalamus

      Targets

      Cellalpha-KlothoFGFR-1FGFR-3FGFR-4
      adrenal cortex Present
      brain Present
      Phenotypes
      • Kallmann syndrome 2
      • olfactory bulb morphogenesis
      cardiac muscle Present
      Phenotypes
      • regulation of cell proliferation
      chondrocyte Present
      		Present
      Phenotypes
      • endochondral ossification
      choroid plexus of telencephalon Present
      distal tubule of nephron Present
      hepatocyte Present
      Reference