Status
Please wait ...

Details for messenger / hormone: CGRP1

EndoNet ID: ENH00228

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • calcitonin gene-related peptide I
  • calcitonin gene-related peptide 1
  • CGRP1
  • CGRP-I
  • alpha-type CGRP

General information

  • Alternative processing of the RNA transcribed from the calcitonin gene results in the production of an mRNA in neural tissue distinct from that in thyroidal 'C' cells. [1]
  • CGRP, a 37-amino acid neuropeptide, is found in the central nervous system as well as in the heart. [2]
  • Adrenomedullin and CGRP interact with a common receptor of the CGRP1 subtype in the human adrenal zona glomerulosa. [3]

Classification

Hormone function

  • homeostasis
    • cardiovascular control

    Chemical classification

    • hormone
      • genome-encoded
        • calcitonin family

      Composition

      isoform 1

      Sequence 
      ACDTATCVT HRLAGLLSR SGGVVKNNF 
VPTNVGSKA F
      UniProt P06881-1

      Links to other resources

      UniProt P06881
      Ensembl ENST00000486207

      • Anatomical structure: nerve

        Influenced by:

        • CB1
          in adrenal_gland
          • Stimulation of the CB1 receptor results in the inhibition of a range of excitatory and inhibitory neurotransmitters, like acetylcholine, noradrenaline, dopamine, 5-hydroxytryptamine, D-aspartate and cholecystokinin. [4]

      • Anatomical structure: hypothalamus

      • Anatomical structure: corpus_striatum

      • Anatomical structure: amygdaloid_body

      • Anatomical structure: cerebellum

      Targets

      Reference