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Details for messenger / hormone: adipsin

EndoNet ID: ENH00232

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Synonyms

  • C3 convertase activator
  • C3 convertase activator
  • adipsin
  • DF
  • ADN
  • properdin factor D
  • complement factor D

General information

  • Adipsin is a serine protease that is secreted by adipocytes into the bloodstream; it is deficient in several animal models of obesity. [1]
  • Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue. [2]
  • Part of the alternative complement pathway; not reduced in human obesity. [3]

Classification

Hormone function

  • metabolism
    • cell metabolism

    Chemical classification

    • hormone
      • genome-encoded
        • peptidase S1 family

      Composition

      Complement factor D

      Sequence 
      ILGGREAEA HARPYMASV QLNGAHLCG 
GVLVAEQWV LSAAHCLED AADGKVQVL 
LGAHSLSQP EPSKRLYDV LRAVPHPDS 
QPDTIDHDL LLLQLSEKA TLGPAVRPL 
PWQRVDRDV APGTLCDVA GWGIVNHAG 
RRPDSLQHV LLPVLDRAT CNRRTHHDG 
AITERLMCA ESNRRDSCK GDSGGPLVC 
GGVLEGVVT SGSRVCGNR KKPGIYTRV 
ASYAAWIDS VLA
      UniProt P00746

      Links to other resources

      UniProt P00746
      Ensembl ENST00000327726
      KEGG hsa:1675

      • Anatomical structure: adipose_tissue

        • Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue. [2]

      • Anatomical structure: fat_cell

        • Adipose tissue is a major site of synthesis of human adipsin/complement factor D mRNA. [2]

      • Anatomical structure: bone_marrow

      • Anatomical structure: hepatocyte

      • Anatomical structure: monocyte

      • Anatomical structure: macrophage

      Targets

      Cell
      No records found.
      Reference