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Details for messenger / hormone: IL-8

EndoNet ID: ENH00235

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Synonyms

  • MDNCF
  • GCP/IL-8 protein III
  • IL8/NAP1 form VI
  • GCP/IL-8 protein VI
  • IL8/NAP1 form V
  • GCP/IL-8 protein V
  • IL8/NAP1 form IV
  • (Ser-IL-8)72
  • GCP/IL-8 protein I
  • IL8/NAP1 form III
  • MDNCF-c
  • neutrophil-activating factor
  • lymphocyte-derived neutrophil-activating factor
  • (Ala-IL-8)77
  • GCP/IL-8 protein II
  • IL8/NAP1 form II
  • MDNCF-b
  • IL-8(1-77)
  • GCP/IL-8 protein IV
  • IL8/NAP1 form I
  • protein 3-10C
  • neutrophil-activating protein 1
  • T-cell chemotactic factor
  • C-X-C motif chemokine 8
  • Interleukin-8
  • IL-8
  • IL8
  • IL 8
  • interleukin 8
  • small inducible cytokine subfamily B, member 8
  • SCYB8
  • monocyte-derived neutrophil chemotactic factor
  • neutrophil-activating peptide 1
  • granulocyte chemotactic protein 1
  • GCP1
  • CXC chemokine ligand 8
  • CXCL8
  • NAP-1
  • NAP1
  • GCP-1
  • monocyte-derived neutrophil-activating peptide
  • MONAP
  • emoctakin

General information

  • IL-8 is produced and released from human adipose tissue and from isolated adipocytes in vitro, which may indicate that IL-8 from adipose tissue could be involved in some of the obesity-related complications. [1]
  • The CXC chemokine interleukin-8 (IL-8/CXCL8) induces rapid mobilization of hematopoietic progenitor cells (HPCs). [2]
  • Insulin enhances vascular endothelial growth factor, interleukin-8, and plasminogen activator inhibitor 1 but not interleukin-6 release by human adipocytes. [3]
  • Angiotensin II stimulates the release of interleukin-6 and interleukin-8 from cultured human adipocytes by activation of NF-kappaB. [4]
  • Circulating levels of IL-18 are also increased in obesity and fall with weight reduction. [5]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • chemokines
            • CXC chemokines

      Composition

      interleukin-8

      Sequence
      AVLPRSAKE LRCQCIKTY SKPFHPKFI 
      KELRVIESG PHCANTEII VKLSDGREL 
      CLDPKENWV QRVVEKFLK RAENS

      Links to other resources

      UniProt P10145
      Ensembl ENST00000307407
      KEGG hsa:3576
      • Anatomical structure: fat_cell

        • IL-8 is produced and released from human adipose tissue and from isolated adipocytes in vitro, which may indicate that IL-8 from adipose tissue could be involved in some of the obesity-related complications. [1]

        Influenced by:

        • insulin receptor
          in fat_cell
          • Insulin enhanced the formation of IL-8. [3]
      • Anatomical structure: adipose_tissue

        • IL-8 is produced and released from human adipose tissue and from isolated adipocytes in vitro, which may indicate that IL-8 from adipose tissue could be involved in some of the obesity-related complications. [1]
      • Anatomical structure: hepatocyte

        • A proinflammatory cytokine gene program that includes C-X-C and C-C chemokines (IL-8, GRO-alpha, GRO-beta, GRO-gamma, ENA-78 and RANTES) and the cytokines TNF-alpha and M-CSF was upregulated in human hepatocytes after stimulation with IL-1a or TNF-alpha or bacterial invasion. In contrast, expression of hematopoietic/ lymphoid growth factors [6]
      • Anatomical structure: T-lymphocyte

      • Anatomical structure: fibroblast

        • The CD40–CD40L interaction has been shown to stimulate prostaglandin and IL-8 release from fibroblasts. [7]
      • Anatomical structure: monocyte

      • Anatomical structure: bronchi

        • The bronchial epithelium is a source not only for the C-X-C chemokines interleukin-8 and GRO-alpha, but also for the neutrophil chemoattractant granulocyte chemotactic protein (GCP)-2. [8]

        Influenced by:

        • IL-17R
          in bronchi
          • Compared to baseline (inherent) release, the peak response of interleukin-17-induced release of interleukin-8 was 225% (+/- 13%). [8]
      • Anatomical structure: Kupffer_cell_stellate_cell_of_liver

        • LPS induces the production of inflammatory chemokines including IL-8 and MCP-1 in activated HSCs. [9]

        Influenced by:

        • TLR4
          in Kupffer_cell_stellate_cell_of_liver
          • LPS directly acts through TLR4 and then activates NF-kappa B and JNK to induce proinflammatory chemokines and adhesion molecules in activated human HSCs. [9]
      • Anatomical structure: lipocyte_of_liver

        • The induction of CXCL8 (IL-8) expression by IL-1 was inhibited by SP600125. [10]
      • Anatomical structure: neutrophil_granulocyte

        Influenced by:

        • TNFR1
          in neutrophil_granulocyte
          • Early TNF-alpha (accumulating 4 hrs after LTA exposure), considerably stimulated the late phase of IL-8 secretion in an autocrine manner. [11]
        • IL-10R-alpha
          in neutrophil_granulocyte
          • IL-10 blocked the late phase of LTA-mediated neutrophil IL-8 synthesis, whereas the early phase (i.e., 8 hrs after stimulation with LTA) of IL-8 synthesis was insensitive to the anti-inflammatory cytokine. [12]
        • EGFR isoform a
          in neutrophil_granulocyte
          • EGF alone was able to prime CD11b expression and IL-8 production by PMN. [13]
      • Anatomical structure: epithelial_cell_with_microvilli

        Influenced by:

        • IL-1RI
          in epithelial_cell_with_microvilli
          • IL-1beta and NE (neutrophil elastase) stimulate IL-8 protein production and activate p38 MAPK in bronchial epithelial cells. [14]
        • TNFR1
          in epithelial_cell_with_microvilli
      • Anatomical structure: cervical_canal_of_uterus

      • Anatomical structure: cholangiocyte

      • Anatomical structure: bronchial_epithelial_cell

        • Protein kinase C delta (PKCδ) mediates LPA-induced NF-κB transcription and interleukin-8 (IL-8) secretion in human bronchial epithelial cells. [15]

        Influenced by:

        • IL-1RI
          in bronchial_epithelial_cell
          • IL-1beta and NE (neutrophil elastase) stimulate IL-8 protein production and activate p38 MAPK in bronchial epithelial cells. [14]
        • TLR4
          in bronchial_epithelial_cell
        • TNFR1
          in bronchial_epithelial_cell
      • Anatomical structure: continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

        • LPA induces expression of cytokines such as IL-8 in vascular endothelial cells. [16]

        Influenced by:

        • Lysophosphatidic acid receptor 3
          in continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics
      • Anatomical structure: pneumocyte_type_II

        Influenced by:

        • IL-1RI
          in pneumocyte_type_II
        • TNFR1
          in pneumocyte_type_II
      • Anatomical structure: monocyte

      • Anatomical structure: dendritic_cell_in_lymphoid_tissues

        Influenced by:

        • TLR3
          in dendritic_cell_in_lymphoid_tissues
          • RNA, likely through secondary structure, is a potent host-derived activator of TLR3. Exposing cells human embryonic kidney 293 cells stably expressing TLR3 and containing a nuclear factor-kB-dependent luciferase reporter) to in vitro transcribed RNA resulted in a TLR3-dependent induction of luciferase activity and interleukin-8 secretion. [17]
      • Anatomical structure: chondrocyte

        • Articular chondrocytes are readily inducible to express the IL-8 gene and secrete biologically active IL-8 [18]

        Influenced by:

        • CMKLR1
          in chondrocyte
          • The results show an increased concentration of IL-8 as a result of chemerin stimulation in comparison to unstimulated control cells [19]

      Targets

      CellCXCR1IL-8R B
      acidophil mammotroph cell of anterior pituitary Present
      Influences
      • PRL
      acidophil somatotroph cell of anterior pituitary Present
      Influences
      • GH
      basophil corticotroph cell of anterior pituitary Present
      Influences
      • ACTH
      basophil gonadotroph cell of anterior pituitary FSH Present
      Influences
      • FSH
      • LH
      basophil thyrotroph cell of anterior pituitary Present
      killer cell Present
      Present
      monocyte Present
      Present
      neutrophil granulocyte Present
      Present
      Reference