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Details for messenger / hormone: oncostatin M

EndoNet ID: ENH00244

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Synonyms

  • Oncostatin-M
  • oncostatin M
  • OSM

General information

  • OSM can modulate expression of the cytokine IL-6 in astrocytes. [1]
  • Oncostatin M induces an acute phase response but does not modulate the growth or maturation-status of liver progenitor (oval) cells in culture. [2]
  • OSM induces smooth muscle cell proliferation. [3]
  • OSM is a 28-kD glycoprotein identified as a growth factor for human multiple myeloma cells. [4]
  • Involved in differentiation of hepatocytes. [5]
  • Oncostatin M (OSM) is a multifunctional cytokine produced by activated T lymphocytes and monocytes that is structurally and functionally related to the subfamily of cytokines known as the IL-6-type cytokine family. [6]

Classification

Hormone function

  • development and growth
    • growth stimulation
    • immune response
      • activation

      Chemical classification

      • hormone
        • genome-encoded
          • cytokines
            • IL-6-type cytokines

        Composition

        Sequence
        AAIGSCSKE YRVLLGQLQ KQTDLMQDT 
        SRLLDPYIR IQGLDVPKL REHCRERPG 
        AFPSEETLR GLGRRGFLQ TLNATLGCV 
        LHRLADLEQ RLPKAQDLE RSGLNIEDL 
        EKLQMARPN ILGLRNNIY CMAQLLDNS 
        DTAEPTKAG RGASQPPTP TPASDAFQR 
        KLEGCRFLH GYHRFMHSV GRVFSKWGE 
        SPNRSRRHS PHQALRKGV RRTRPSRKG 
        KRLMTRGQL PR

        Links to other resources

        UniProt P13725
        Ensembl ENST00000215781
        KEGG hsa:5008
        • Anatomical structure: monocyte

          • OSM is produced by activated monocyte and T-lymphocyte cell lines. [7]
        • Anatomical structure: osteoblast

        • Anatomical structure: bronchial_epithelial_cell

        • Anatomical structure: epithelial_cell_with_microvilli

        • Anatomical structure: T-lymphocyte

        Targets

        Reference