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Details for messenger / hormone: HGF

EndoNet ID: ENH00245

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Synonyms

  • Hepatopoeitin-A
  • HGF
  • hepatocyte growth factor
  • scatter factor
  • SF
  • lung fibroblast-derived mitogen
  • hepatopoietin A
  • HPTA
  • scattering factor

General information

  • HGF plays a role in the growth of hepatoblasts. [1]
  • Hepatocyte growth factor/scatter factor is a motogen for interneurons migrating from the ventral to dorsal telencephalon. [2]
  • Alternative splicing.
  • HGF inhibits bone formation in multiple myeloma. [3]
  • Hepatocyte growth factor and its receptor are required for malaria infection. [4]
  • HGF contributes to cell migration by assisting cytoplasmic accumulation of laminin gamma-2-chains in invading carcinoma cells. [5]
  • Hepatocyte growth factor (HGF) is a plasminogen-like protein thought to be a humoral mediator of liver regeneration. [6]
  • Hepatocyte growth factor/scatter factor (HGF/SF) functions as a mitogen, motogen and morphogen for a variety of cultured cells. [7]
  • Scatter factor/hepatocyte growth factor is essential for liver development. [8]
  • HGF is the most potent mitogen for mature parenchymal hepatocytes in primary culture, and seems to be a hepatotrophic factor that acts as a trigger for liver regeneration after partial hepatectomy and liver injury. [9]
  • The effects of HGF and epidermal growth factor (EGF) are additive. [9]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    Composition

    Hepatocyte growth factor beta chain (1 times)

    • Dimer of an alpha chain and a beta chain linked by a disulfide bond.
    Sequence
    VVNGIPTRT NIGWMVSLR YRNKHICGG 
    SLIKESWVL TARQCFPSR DLKDYEAWL 
    GIHDVHGRG DEKCKQVLN VSQLVYGPE 
    GSDLVLMKL ARPAVLDDF VSTIDLPNY 
    GCTIPEKTS CSVYGWGYT GLINYDGLL 
    RVAHLYIMG NEKCSQHHR GKVTLNESE 
    ICAGAEKIG SGPCEGDYG GPLVCEQHK 
    MRMVLGVIV PGRGCAIPN RPGIFVRVA 
    YYAKWIHKI ILTYKVPQS

    Hepatocyte growth factor alpha chain (1 times)

    • Dimer of an alpha chain and a beta chain linked by a disulfide bond.
    Sequence
    QRKRRNTIH EFKKSAKTT LIKIDPALK 
    IKTKKVNTA DQCANRCTR NKGLPFTCK 
    AFVFDKARK QCLWFPFNS MSSGVKKEF 
    GHEFDLYEN KDYIRNCII GKGRSYKGT 
    VSITKSGIK CQPWSSMIP HEHSFLPSS 
    YRGKDLQEN YCRNPRGEE GGPWCFTSN 
    PEVRYEVCD IPQCSEVEC MTCNGESYR 
    GLMDHTESG KICQRWDHQ TPHRHKFLP 
    ERYPDKGFD DNYCRNPDG QPRPWCYTL 
    DPHTRWEYC AIKTCADNT MNDTDVPLE 
    TTECIQGQG EGYRGTVNT IWNGIPCQR 
    WDSQYPHEH DMTPENFKC KDLRENYCR 
    NPDGSESPW CFTTDPNIR VGYCSQIPN 
    CDMSHGQDC YRGNGKNYM GNLSQTRSG 
    LTCSMWDKN MEDLHRHIF WEPDASKLN 
    ENYCRNPDD DAHGPWCYT GNPLIPWDY 
    CPISRCEGD TTPTIVNLD HPVISCAKT 
    KQLR

    Links to other resources

    UniProt P14210
    Ensembl ENST00000222390
    KEGG hsa:3082
    • Anatomical structure: placenta

      • Localisation of hepatocyte growth factor and its receptor (c-met) protein and mRNA in human term placenta. [10]
    • Anatomical structure: hepatocyte

      • Forced HGF expression by cultured human hepatocytes had a mitogenic effect. [11]

    Targets

    Cellhepatocyte growth factor receptor
    colon Present
    continuous vascular endothelial cell of blood vessels and lymphatics Present
    Phenotypes
    • positive regulation of cell growth
    digestive system Present
    epithelial cell Present
    Phenotypes
    • branching morphogenesis
    • positive regulation of cell growth
    hepatocyte Present
    kidney Present
    placenta Present
    small intestine Present
    stomach Present
    thyroid gland Present
    umbilical vein endothelial cells Present
    vascularendothelial cell Present
    Reference