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Details for messenger / hormone: CNTF

EndoNet ID: ENH00249

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Synonyms

  • ciliary neurotrophic factor
  • CNTF

General information

  • CNTF is a neurocytokine expressed in glial cells that acts on brain cells to promote gene expression, survival, and differentiation. [1]
  • Ciliary neurotrophic factor regulates fibrinogen gene expression in hepatocytes by binding to the interleukin-6 receptor. [2]
  • Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity. [3]
  • Ciliary neurotrophic factor induces acute-phase protein expression in hepatocytes. [4]
  • Ciliary neurotrophic factor upregulates ubiquitin-proteasome components in a rat model of neuronal injury. [5]
  • IL-6-type cytokine, stimulates type-2 acute phase proteins, such as fibrinogen, alpha-1-antitrypsin, haptoglobin and ceruloplasmin. [6]

Classification

Hormone function

  • metabolism
    • cell metabolism

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • IL-6-type cytokines

      Composition

      Sequence 
      MAFTEHSPL TPHRRDLCS RSIWLARKI 
RSDLTALTE SYVKHQGLN KNINLDSAD 
GMPVASTDQ WSELTEAER LQENLQAYR 
TFHVLLARL LEDQQVHFT PTEGDFHQA 
IHTLLLQVA AFAYQIEEL MILLEYKIP 
RNEADGMPI NVGDGGLFE KKLWGLKVL 
QELSQWTVR SIHDLRFIS SHQTGIPAR 
GSHYIANNK KM

      Links to other resources

      UniProt P26441
      Ensembl ENST00000361987
      KEGG hsa:1270

      • Anatomical structure: nerve

        • CNTF mRNA is widely expressed in the brain, heart, lung, liver, kidney and testis of the rat, in addition to preferential expression in the sciatic nerve. [7]

      • Anatomical structure: heart

        • CNTF mRNA is widely expressed in the brain, heart, lung, liver, kidney and testis of the rat, in addition to preferential expression in the sciatic nerve. [7]

      • Anatomical structure: lung

        • CNTF mRNA is widely expressed in the brain, heart, lung, liver, kidney and testis of the rat, in addition to preferential expression in the sciatic nerve. [7]

      • Anatomical structure: kidney

        • CNTF mRNA is widely expressed in the brain, heart, lung, liver, kidney and testis of the rat, in addition to preferential expression in the sciatic nerve. [7]

      • Anatomical structure: testis

        • CNTF mRNA is widely expressed in the brain, heart, lung, liver, kidney and testis of the rat, in addition to preferential expression in the sciatic nerve. [7]

      • Anatomical structure: osteoblast

      • Anatomical structure: central_nerve_system_element

        • CNTF ia expressed in glia cells within the CNS [8]

      Targets

      CellCNTFR
      hypothalamus Present
      Phenotypes
      • positive regulation of neurogenesis
      Reference