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Details for messenger / hormone: cardiotrophin 1

EndoNet ID: ENH00250

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Synonyms

  • CT1
  • CT-1
  • cardiotrophin-1
  • cardiotrophin 1
  • CTF1
  • CTF 1
  • CTF-1

General information

  • Six different cytokines that share GP130 as a receptor subunit, induce serum amyloid A and potentiate the induction of interleukin-6 and the activation of the hypothalamus-pituitary-adrenal axis by interleukin-1. [1]
  • Cardiotrophin-1, a cytokine present in embryonic muscle, supports long-term survival of spinal motoneurons. [2]
  • CT-1, a novel cytokine belonging to the IL-6 cytokine family, is a hepatocyte stimulating factor. [3]
  • CT-1 is a potent neurotrophic factor for motoneurons but its clinical use in motor neuron diseases is precluded by side effects on the heart and liver. [4]
  • Cardiotrophin 1 is a cytokine that induces cardiac myocyte hypertrophy. [5]
  • The IL (interleukin)-6-type cytokines IL-6, IL-11, LIF (leukaemia inhibitory factor), OSM (oncostatin M), ciliary neurotrophic factor, cardiotrophin-1 and cardiotrophin-like cytokine are an important family of mediators involved in the regulation of the acute-phase response to injury and infection. [6]
  • CT-1 and VEGF are hepatoprotective mediators upregulated at 24 hours after partial hepatectomy. [7]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • IL-6-type cytokines

      Composition

      Sequence
      MSRREGSLE DPQTDSSVS LLPHLEAKI 
      RQTHSLAHL LTKYAEQLL QEYVQLQGD 
      PFGLPSFSP PRLPVAGLS APAPSHAGL 
      PVHERLRLD AAALAALPP LLDAVCRRQ 
      AELNPRAPR LLRRLEDAA RQARALGAA 
      VEALLAALG AANRGPRAE PPAATASAA 
      SATGVFPAK VLGLRVCGL YREWLSRTE 
      GDLGQLLPG GSA
      UniProt Q16619

      Links to other resources

      UniProt Q16619
      Ensembl ENST00000279804
      KEGG hsa:1489
      • Anatomical structure: heart

        • Cardiotrophin-1 displays early expression in the murine heart tube and promotes cardiac myocyte survival. [8]
      • Anatomical structure: osteoblast

      • Anatomical structure: skeleton_muscle

      • Anatomical structure: ovary

      • Anatomical structure: colon

      • Anatomical structure: lung

      • Anatomical structure: hepatocyte

        • CT-1 is up-regulated during liver regeneration and exerts potent antiapoptotic effects on hepatocytic cells. [9]
      • Anatomical structure: prostate

      Targets

      Reference