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Details for messenger / hormone: IL-11

EndoNet ID: ENH00251

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Synonyms

  • Interleukin-11
  • adipogenesis inhibitory factor
  • AGIF
  • oprelvekin
  • IL-11
  • interleukin 11
  • IL11
  • IL 11

General information

  • A protective role of interleukin 11 on hepatic injury in acute endotoxemia. [1]
  • IL-6-type cytokine, stimulates type-2 acute phase proteins, such as fibrinogen, alpha-1-antitrypsin, haptoglobin and ceruloplasmin. [2]
  • IL-11 has an important function in implantation in humans. [3]
  • Interleukin-6 (IL-6), leukemia inhibitory factor, oncostatin M, IL-11, and ciliary neurotropic factor are a family of cytokines and neuronal differentiation factors which bind to composite plasma membrane receptors sharing the signal transducing subunit gp130 [4]
  • Regulation of hepatic cytochrome P450 2C11 by transforming growth factor-beta, hepatocyte growth factor, and interleukin-11. [5]
  • Cytokines in interleukin (IL)-11 subfamily participate in the regulation of bone cell proliferation and differentiation. [6]
  • Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. [7]
  • IL-11 appears to play an important role in hematopoiesis, bone metabolism and tissue remodeling and may be an important protector of mucosal surfaces. [8]

Classification

Hormone function

  • immune response
    • inhibition

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • IL-6-type cytokines

      Composition

      Sequence
      PGPPPGPPR VSPDPRAEL DSTVLLTRS 
      LLADTRQLA AQLRDKFPA DGDHNLDSL 
      PTLAMSAGA LGALQLPGV LTRLRADLL 
      SYLRHVQWL RRAGGSSLK TLEPELGTL 
      QARLDRLLR RLQLLMSRL ALPQPPPDP 
      PAPPLAPPS SAWGGIRAA HAILGGLHL 
      TLDWAVRGL LLLKTRL

      Links to other resources

      UniProt P20809
      Ensembl ENST00000264563
      KEGG hsa:3589
      • Anatomical structure: bone_marrow

      • Anatomical structure: epithelial_cell

        • IL-11 is produced by a variety of stromal cells including fibroblasts, epithelial cells and osteoblasts. [8]
      • Anatomical structure: osteoblast

        • IL-11 is produced by a variety of stromal cells including fibroblasts, epithelial cells and osteoblasts. [8]
        • IL-11 is an IL-6-type cytokine, which inhibits adipogenesis and activates osteoclasts. [9]

        Influenced by:

        • beta-2 adrenoreceptor
          in osteoblast
          • Interleukin-6 and interleukin-11 synthesis is stimulated by epinephrine in human osteoblasts. [9]
      • Anatomical structure: Kupffer_cell_stellate_cell_of_liver

        • Hepatocytes did not express IL-11. [10]
      • Anatomical structure: cell_of_endometrium_of_uterus

        • IL-11 is expressed in endometrial glandular and luminal epithelium. [3]
        • IL-11 and IL-11Ralpha are also reduced in endometrium in cohorts of women with infertility and endometriosis compared with fertile women during the window of implantation. [3]
        • In contrast to LIF, IL-11 mRNA expression and immunostaining is reduced in decidua and trophoblast in women with anembryonic pregnancies that result in early abortion, compared with normal pregnancies. [3]
        • IL-11 secretion and mRNA expression by human endometrial stromal cells are stimulated by locally produced factors, relaxin and prostaglandin estradiol (E2), acting at least in part via cAMP during human endometrial stromal cell decidualization although progesterone attenuates IL-11 secretion and mRNA expression. [3]

        Influenced by:

        • progesterone receptor
          in cell_of_endometrium_of_uterus
          • Progesterone attenuates IL-11 secretion and mRNA expression. [3]
        • ER-alpha
          in cell_of_endometrium_of_uterus
          • IL-11 secretion is reduced by co-culture with estrogen and progesterone but stimulated by estrogen alone. [3]
        • Prokineticin receptor 1
          in cell_of_endometrium_of_uterus
          • In the present study, we report that PROK1 induces the expression and secretion of the cytokine IL-11 in cultured endometrial epithelial cells and first trimester decidua explants via the PK-1 receptor. [11]
      • Anatomical structure: osteoblast

      Targets

      Reference