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Details for messenger / hormone: IL-4

EndoNet ID: ENH00252

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Synonyms

  • Pitrakinra
  • Binetrakin
  • Interleukin-4
  • IL-4
  • IL4
  • IL 4
  • interleukin 4
  • B-cell stimulatory factor 1
  • BSF-1
  • lymphocyte stimulatory factor 1
  • BSF1

General information

  • IL4 and IL13 have a protective role in hepatic injury in the ischaemia/perfusion model that depended on the activation of STAT6. [1]
  • IL-4 activates gene expression by inducing tyrosine phosphorylation, homodimerization, and nuclear translocation of the latent transcription factor, STAT6. [2]
  • Activates the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling cascades, which may contribute to allergic responses. [3]
  • IL-4 receptor expression on CD8+ T cells is required for the development of protective memory responses against liver stages of malaria parasites. [4]
  • IL4 is an 18-kD glycoprotein.
  • Alternative splicing.
  • IL-4 and IL-13 directly affected hepatic stellate cells by increasing collagen production and suppressing cell proliferation. [5]
  • IL-4 protects against endotoxemia. [6]
  • Anti-inflammatory cytokine. [7]
  • IL-4 suppresses the expression and the replication of hepatitis B virus in the hepatocellular carcinoma cell line Hep3B. [8]

Classification

Hormone function

  • immune response
    • activation
      • inhibition

      Chemical classification

      • hormone
        • genome-encoded
          • cytokines

      Composition

      Interleukin-4

      Sequence
      HKCDITLQE IIKTLNSLT EQKTLCTEL 
      TVTDIFAAS KNTTEKETF CRAATVLRQ 
      FYSHHEKDT RCLGATAQQ FHRHKQLIR 
      FLKRLDRNL WGLAGLNSC PVKEANQST 
      LENFLERLK TIMREKYSK CSS
      UniProt P05112

      Links to other resources

      UniProt P05112
      Ensembl ENST00000231449
      KEGG hsa:3565
      • Anatomical structure: muscle

        • IL-4 is expressed by a subset of muscle cells in fusing muscle cultures and requires the IL-4alpha receptor subunit on myoblasts to promote fusion and growth. [9]
      • Anatomical structure: mast_cell

        • IL-4 and IL-13 are two cytokines produced by T helper type 2 cells, mast cells, and basophils. [3]
      • Anatomical structure: basophil_granulocyte

        • IL-4 and IL-13 are two cytokines produced by T helper type 2 cells, mast cells, and basophils. [3]
      • Anatomical structure: T-lymphocyte

        • IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages. [10]
      • Anatomical structure: helper_T_cell_Th2

        • Th1 cells mainly produce interferon-gamma, while Th2 cells selectively secrete IL-4 and IL-5. [11]
      • Anatomical structure: helper_T_cell_Th1

        • IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages. [10]

      Targets

      CellIL-4R type lIL-4RalphaIL4R type ll
      B-lymphocyte Present
      Influences
      • IgE
      Present
      bronchial epithelial cell Present
      dendritic cell in lymphoid tissues follicular Present
      epithelial cell with microvilli Present
      monocyte Present
      Influences
      • IL-12B
      • IL-12
      • IL-10
      • interleukin 6
      osteoblast Present
      Influences
      • interleukin 6
      • PGE2
      propria mucosa of bronchus Present
      T-lymphocyte Present
      Reference