Please wait ...

Details for messenger / hormone: IL-13

EndoNet ID: ENH00253

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be:

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like
If the search pattern is unambigious the user is directed to the corresponding detail page.


  • Interleukin-13
  • IL-13
  • IL13
  • interleukin 13
  • IL 13
  • NC30
  • P600

General information

  • Activate the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling cascades, which may contribute to allergic responses. [1]
  • IL-13 is a critical hepatoprotective factor modulating the susceptibility to acetaminophen-induced liver disease. [2]
  • Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. [3]
  • IL-13 appears to play a more dominant role than IL-4 in the expulsion of certain gastrointestinal parasites. [4]
  • IL-13 pathways contributes to gene regulation in airway epithelial cells. [5]
  • IL-13 is a critical effector cytokine driving cellular recruitment and subsequent fibrosis in clinical and ex-perimental bronchiolitis obliterans. [6]
  • IL4 and IL13 have a protective role in hepatic injury in the ischaemia/perfusion model that depended on the activation of STAT6. [7]
  • Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses. [8]
  • IL-13 contributes to the development of a late nasal response with little influence on the early response, and without affecting nasal eosinophilic inflammation. [9]
  • IL-13 is overproduced in asthma and has implicated IL-13 in the pathogenesis of the Th2 inflammation. [10]
  • IL-4 and IL-13 directly affected hepatic stellate cells by increasing collagen production and suppressing cell proliferation. [11]
  • IL-13 contributes to fatal allergic inflammation during Cryptococcus neoformans infection. [12]


Hormone function

  • immune response
    • activation
      • inhibition

      Chemical classification

      • hormone
        • genome-encoded
          • cytokines



      Links to other resources

      UniProt P35225
      Ensembl ENST00000304506
      KEGG hsa:3596
      • Anatomical structure: thyroid_gland

        • IL-13 is an important mediator of antiinflammatory immune responses and is expressed in the thyroid and orbit. [13]
      • Anatomical structure: basophil_granulocyte

        • IL-4 and IL-13 are two cytokines produced by T helper type 2 cells, mast cells, and basophils. [1]
      • Anatomical structure: mast_cell

        • IL-4 and IL-13 are two cytokines produced by T helper type 2 cells, mast cells, and basophils. [1]
      • Anatomical structure: lymphocyte

        • IL-13 is a pleiotropic cytokine produced in large quantities by activated CD4(+) Th2 lymphocytes. [14]
      • Anatomical structure: skin

      • Anatomical structure: leukocyte

      • Anatomical structure: T-lymphocyte

        • Interleukin 13 is a T-cell-derived cytokine that regulates human monocyte and B-cell function. [15]
      • Anatomical structure: lung

        • Increased lung inflammation and the overexpression of soluble mediators such as IL-13, IL-1beta, IFN-gamma and VEGF are important in the pathogenesis of human as well as experimental emphysema. [16]
      • Anatomical structure: helper_T_cell_Th2


      CellIL-4RalphaIL4R type ll
      B-lymphocyte Present
      bronchial epithelial cell Present
      dendritic cell in lymphoid tissues follicular Present
      epithelial cell with microvilli Present
      osteoblast Present
      • interleukin 6
      • PGE2
      propria mucosa of bronchus Present
      T-lymphocyte Present