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Details for messenger / hormone: IL-13

EndoNet ID: ENH00253

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Synonyms

  • Interleukin-13
  • IL-13
  • IL13
  • interleukin 13
  • IL 13
  • NC30
  • P600

General information

  • Activate the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling cascades, which may contribute to allergic responses. [1]
  • IL-13 is a critical hepatoprotective factor modulating the susceptibility to acetaminophen-induced liver disease. [2]
  • Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. [3]
  • IL-13 appears to play a more dominant role than IL-4 in the expulsion of certain gastrointestinal parasites. [4]
  • IL-13 pathways contributes to gene regulation in airway epithelial cells. [5]
  • IL-13 is a critical effector cytokine driving cellular recruitment and subsequent fibrosis in clinical and ex-perimental bronchiolitis obliterans. [6]
  • IL4 and IL13 have a protective role in hepatic injury in the ischaemia/perfusion model that depended on the activation of STAT6. [7]
  • Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses. [8]
  • IL-13 contributes to the development of a late nasal response with little influence on the early response, and without affecting nasal eosinophilic inflammation. [9]
  • IL-13 is overproduced in asthma and has implicated IL-13 in the pathogenesis of the Th2 inflammation. [10]
  • IL-4 and IL-13 directly affected hepatic stellate cells by increasing collagen production and suppressing cell proliferation. [11]
  • IL-13 contributes to fatal allergic inflammation during Cryptococcus neoformans infection. [12]

Classification

Hormone function

  • immune response
    • activation
      • inhibition

      Chemical classification

      • hormone
        • genome-encoded
          • cytokines

      Composition

      Sequence 
      GPVPPSTAL RELIEELVN ITQNQKAPL 
CNGSMVWSI NLTAGMYCA ALESLINVS 
GCSAIEKTQ RMLSGFCPH KVSAGQFSS 
LHVRDTKIE VAQFVKDLL LHLKKLFRE 
GRFN

      Links to other resources

      UniProt P35225
      Ensembl ENST00000304506
      KEGG hsa:3596

      • Anatomical structure: thyroid_gland

        • IL-13 is an important mediator of antiinflammatory immune responses and is expressed in the thyroid and orbit. [13]

      • Anatomical structure: basophil_granulocyte

        • IL-4 and IL-13 are two cytokines produced by T helper type 2 cells, mast cells, and basophils. [1]

      • Anatomical structure: mast_cell

        • IL-4 and IL-13 are two cytokines produced by T helper type 2 cells, mast cells, and basophils. [1]

      • Anatomical structure: lymphocyte

        • IL-13 is a pleiotropic cytokine produced in large quantities by activated CD4(+) Th2 lymphocytes. [14]

      • Anatomical structure: skin

      • Anatomical structure: leukocyte

      • Anatomical structure: T-lymphocyte

        • Interleukin 13 is a T-cell-derived cytokine that regulates human monocyte and B-cell function. [15]

      • Anatomical structure: lung

        • Increased lung inflammation and the overexpression of soluble mediators such as IL-13, IL-1beta, IFN-gamma and VEGF are important in the pathogenesis of human as well as experimental emphysema. [16]

      • Anatomical structure: helper_T_cell_Th2

      Targets

      CellIL-4RalphaIL4R type ll
      B-lymphocyte Present
      bronchial epithelial cell Present
      dendritic cell in lymphoid tissues follicular Present
      epithelial cell with microvilli Present
      osteoblast Present
      Influences
      • ↓ interleukin 6
      • ↓ PGE2
      propria mucosa of bronchus Present
      T-lymphocyte Present
      Reference