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Details for messenger / hormone: IL-12A

EndoNet ID: ENH00254

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Synonyms

  • CLMF p35
  • cytotoxic lymphocyte maturation factor 35 kDa subunit
  • IL-12 subunit p35
  • interleukin-12 subunit alpha
  • IL-12A
  • interleukin 12A
  • IL12 subunit p35
  • cytotoxic lymphocyte maturation factor
  • CLMF
  • IL12A
  • NKSF1
  • NK cell stimulatory factor chain 1
  • cytotoxic lymphocyte maturation factor 35kDa subunit
  • interleukin-12 alpha chain

General information

  • Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.
  • Disulfide-bonded heterodimer of 40 kDa and 35 kDa subunits. NKSF is essentially a complex of cytokine and soluble receptor.

Classification

Hormone function

  • development and growth
    • growth stimulation
    • immune response
      • activation

      Chemical classification

      • hormone
        • genome-encoded
          • cytokines
            • IL-6-type cytokines

        Composition

        Sequence 
        RNLPVATPD PGMFPCLHH SQNLLRAVS 
NMLQKARQT LEFYPCTSE EIDHEDITK 
DKTSTVEAC LPLELTKNE SCLNSRETS 
FITNGSCLA SRKTSFMMA LCLSSIYED 
LKMYQVEFK TMNAKLLMD PKRQIFLDQ 
NMLAVIDEL MQALNFNSE TVPQKSSLE 
EPDFYKTKI KLCILLHAF RIRAVTIDR 
VMSYLNAS

        Links to other resources

        UniProt P29459
        Ensembl ENST00000305579
        KEGG hsa:3592

        • Anatomical structure: B-lymphocyte

        • Anatomical structure: macrophage

        • Anatomical structure: monocyte

          • The correlation between p35 mRNA expression and p70 production accompanied by an overproduction of p40 in LPS-stimulated monocytes implies that the expression of the p35 mRNA is the limiting step in the regulation of IL- 12 production. [1]

          Influenced by:

          • IL-10R-alpha
            in monocyte
            • IL-10 inhibited both IL-12A(p35) and IL-12B(p40) mRNA expression. [1]
            • IL-10 inhibited p35 stronger than p40. [1]

        Targets

        Cell
        No records found.
        Reference