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Details for messenger / hormone: IL-12B

EndoNet ID: ENH00255

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Synonyms

  • interleukin 12B
  • IL-12 subunit p40
  • interleukin-12 subunit beta
  • cytotoxic lymphocyte maturation factor 2
  • CLMF2
  • natural killer cell stimulatory factor 40kDa subunit
  • NKSF2
  • cytotoxic lymphocyte maturation factor 40 kDa subunit
  • CLMF p40
  • NK cell stimulatory factor chain 2
  • IL-12B
  • IL12B
  • IL 12B
  • IL12 subunit p40
  • IL23 subunit p40

General information

  • Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
  • IL-12 governs the Th1-type immune response, affecting the spontaneous and treatment-induced recovery from HCV-infection. [1]
  • Functional polymorphisms in IL-12p40 (IL12B) were found to be associated with susceptibility to several autoimmune diseases. [2]
  • Disulfide-bonded heterodimer of 40 kDa and 35 kDa subunits. NKSF is essentially a complex of cytokine and soluble receptor.
  • See IL12A.
  • Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair. [3]
  • The IL12B gene is associated with asthma. [4]
  • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. [5]

Classification

Hormone function

  • development and growth
    • growth stimulation
    • immune response
      • activation

      Chemical classification

      • hormone
        • genome-encoded
          • cytokines

      Composition

      Sequence 
      IWELKKDVY VVELDWYPD APGEMVVLT 
CDTPEEDGI TWTLDQSSE VLGSGKTLT 
IQVKEFGDA GQYTCHKGG EVLSHSLLL 
LHKKEDGIW STDILKDQK EPKNKTFLR 
CEAKNYSGR FTCWWLTTI STDLTFSVK 
SSRGSSDPQ GVTCGAATL SAERVRGDN 
KEYEYSVEC QEDSACPAA EESLPIEVM 
VDAVHKLKY ENYTSSFFI RDIIKPDPP 
KNLQLKPLK NSRQVEVSW EYPDTWSTP 
HSYFSLTFC VQVQGKSKR EKKDRVFTD 
KTSATVICR KNASISVRA QDRYYSSSW 
SEWASVPCS

      Links to other resources

      UniProt P29460
      Ensembl ENST00000231228
      KEGG hsa:3593

      • Anatomical structure: monocyte

        Influenced by:

        • IL-4R type l
          in monocyte
          • IL-4 decreased p40 production 8- to 30-fold. [6]
        • IL-10R-alpha
          in monocyte
          • IL-10 inhibited IL-12(p70) completely, and IL-12B(p40) about 10-fold. [6]

      • Anatomical structure: B-lymphocyte

      • Anatomical structure: T-lymphocyte

      Targets

      Cell
      No records found.
      Reference