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Details for messenger / hormone: PDGFA

EndoNet ID: ENH00257

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Synonyms

  • platelet-derived growth factor alpha polypeptide
  • platelet-derived growth factor subunit A
  • PDGFA
  • platelet-derived growth factor A chain
  • PDGF A
  • PDGF-1
  • PDGF-AA

General information

  • Antiparallel disulfide-linked dimer of nonidentical (A and B) chains. Homodimers of A and B chains are implicated in transformation processes.
  • Growth factor responsible for potent autocrine stimulation of abnormal cell proliferation. [1]
  • PDGF is a potent mitogenic and migratory factor that regulates the tyrosine phosphorylation of a variety of signalling proteins via intracellular production of H2O2. [2]
  • NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. [3]

Classification

Hormone function

  • development and growth
    • growth stimulation
      • embryogenesis

      Chemical classification

      • hormone
        • genome-encoded
          • cytokines
            • PDGF/VEGF growth factor family

        Composition

        A chain

        Sequence
        SIEEAVPAV CKTRTVIYE IPRSQVDPT 
        SANFLIWHL ECACATTSL NPDYREEDT 
        GRPRESGKK RKRKRLKPT

        Links to other resources

        UniProt P04085
        Ensembl ENST00000354513
        KEGG hsa:5154
        • Anatomical structure: Kupffer_cell_stellate_cell_of_liver

        • Anatomical structure: mast_cell

        • Anatomical structure: continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

          • Human endothelial cells express platelet-derived growth factor B chain. [5]

        Targets

        CellPDGFRalpha
        fibroblast Present
        Phenotypes
        • proliferation of fibroblasts
        Reference