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Details for messenger / hormone: PDGFB

EndoNet ID: ENH00258

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Synonyms

  • PDGFB
  • platelet-derived growth factor subunit B
  • PDGF B
  • platelet-derived growth factor B chain
  • platelet-derived growth factor beta polypeptide
  • PDGF-2
  • c-sis
  • becaplermin
  • oncogene sis
  • simian sarcoma viral oncogene homolog
  • SSV
  • PDGF-BB

General information

  • PDGF B chain alone is sufficient for mitogenesis. [1]
  • Antiparallel disulfide-linked dimer of nonidentical (A and B) chains. Homodimers of A and B chains are implicated in transformation processes.
  • Growth factor responsible for potent autocrine stimulation of abnormal cell proliferation. [2]
  • PDGF is a potent mitogenic and migratory factor that regulates the tyrosine phosphorylation of a variety of signalling proteins via intracellular production of H2O2. [3]
  • NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. [4]

Classification

Hormone function

  • development and growth
    • growth stimulation
      • embryogenesis

      Chemical classification

      • hormone
        • genome-encoded
          • cytokines
            • PDGF/VEGF growth factor family

        Composition

        B chain (2 times)

        Sequence 
        SLGSLTIAE PAMIAECKT RTEVFEISR 
RLIDRTNAN FLVWPPCVE VQRCSGCCN 
NRNVQCRPT QVQLRPVQV RKIEIVRKK 
PIFKKATVT LEDHLACKC ETVAAARPV 
T

        Links to other resources

        UniProt P01127
        Ensembl ENST00000396740
        KEGG hsa:5155

        • Anatomical structure: continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

          • Human endothelial cells express platelet-derived growth factor B chain. [5]
          • Recruitment of mesengial cells into the developing vascular tuft is dependent upon endothelial cell secretion of platelet-derived growth factor B. [6]

        • Anatomical structure: fibroblast

        Targets

        CellPDGFRPDGFRalphaPDGFRbeta
        fibroblast Present
        Phenotypes
        • proliferation of fibroblasts
        lipocyte of liver Present
        Phenotypes
        • regulation of tissue remodeling
        		Present
        Phenotypes
        • regulation of tissue remodeling
        Reference