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Details for messenger / hormone: IFN-alpha

EndoNet ID: ENH00261

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Synonyms

  • IFN-alpha
  • interferon alpha-D
  • IFNA1
  • interferon alpha-1/13
  • IFNA13
  • LeIF D

General information

  • Produced bby macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase
  • IFN-alpha was detected primarily in inflammatory cells (plasma cells, lymphocytes, macrophages) in the portal tract and in Kupffer cells. [1]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • interferons

      Composition

      Sequence 
      CDLPETHSL DNRRTLMLL AQMSRISPS 
SCLMDRHDF GFPQEEFDG NQFQKAPAI 
SVLHELIQQ IFNLFTTKD SSAAWDEDL 
LDKFCTELY QQLNDLEAC VMQEERVGE 
TPLMNADSI LAVKKYFRR ITLYLTEKK 
YSPCAWEVV RAEIMRSLS LSTNLQERL 
RRKE

      Links to other resources

      UniProt P01562
      Ensembl ENST00000276927
      KEGG hsa:3447

      • Anatomical structure: monocyte

      • Anatomical structure: Kupffer_cell_stellate_cell_of_liver

        • In liver parenchyma, IFN-alpha was mainly detected in Kupffer cells, and not in hepatocytes. [2]

      • Anatomical structure: dendritic_cell_in_lymphoid_tissues

        • DCs express IFN-alpha, IFN-beta, IL-28, IL-29, TNF-alpha and the chemokines CCL5 and CXCL10 after herpes simplex virus 1 (HSV-1) infection. [3]

        Influenced by:

        • TLR3
          in dendritic_cell_in_lymphoid_tissues
          • TLR3, TLR7, and TLR9 can induce both IFN-alpha and IFN-beta. [4]
        • TLR7
          in dendritic_cell_in_lymphoid_tissues
        • TLR9
          in dendritic_cell_in_lymphoid_tissues

      • Anatomical structure: macrophage

        Influenced by:

        • TLR4
          in macrophage

      Targets

      Reference