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Details for messenger / hormone: IFN-beta

EndoNet ID: ENH00263

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Synonyms

  • IFN-beta
  • interferon beta
  • fibroblast interferon
  • IFB
  • IFNB
  • IFNB1
  • interferon beta 1

General information

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • interferons

      Composition

      Sequence 
      MSYNLLGFL QRSSNFQCQ KLLWQLNGR 
LEYCLKDRM NFDIPEEIK QLQQFQKED 
AALTIYEML QNIFAIFRQ DSSSTGWNE 
TIVENLLAN VYHQINHLK TVLEEKLEK 
EDFTRGKLM SSLHLKRYY GRILHYLKA 
KEYSHCAWT IVRVEILRN FYFINRLTG 
YLRN

      Links to other resources

      UniProt P01574
      Ensembl ENST00000380232
      KEGG hsa:3456

      • Anatomical structure: fibroblast

      • Anatomical structure: macrophage

        • Human monocyte-derived macrophages express IFN-alpha, IFN-beta, IL-28, IL-29, TNF-alpha and the chemokines CCL5 and CXCL10 after herpes simplex virus 1 (HSV-1) infection. [1]

        Influenced by:

        • TLR4
          in macrophage
          • With LPS in the presence of LPS-binding protein TLR4 activates the common MyD88-dependent signaling pathway as well as a MyD88-independent pathway leading to interferon-beta production. [2]

      • Anatomical structure: dendritic_cell_in_lymphoid_tissues

        Influenced by:

        • TLR3
          in dendritic_cell_in_lymphoid_tissues
          • TLR3, TLR7, and TLR9 can induce both IFN-alpha and IFN-beta. [3]
        • TLR7
          in dendritic_cell_in_lymphoid_tissues
        • TLR9
          in dendritic_cell_in_lymphoid_tissues
        • TLR4
          in dendritic_cell_in_lymphoid_tissues
          • TLR4 can lead to IFN-beta production. [3]

      Targets

      CellIFNAR2
      monocyte Present
      Influences
      • ↑ CXCL11
      Reference