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Details for messenger / hormone: IFN-gamma

EndoNet ID: ENH00265

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Synonyms

  • IFN-gamma
  • IFNg
  • immune interferon
  • interferon gamma

General information

  • IFN-gamma inhibits multinucleated cells (MNC) formation, and inhibits bone resorption in part by inhibiting osteoclast formation. [1]
  • Interferon gamma is also the ultimate mediator of IL-32 in synthesis induced by mycobacteria [2]
  • IFN-gamma displays a high affinity for heparan sulfate. [3]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • interferons

      Composition

      Sequence 
      CYCQDPYVK EAENLKKYF NAGHSDVAD 
NGTLFLGIL KNWKEESDR KIMQSQIVS 
FYFKLFKNF KDDQSIQKS VETIKEDMN 
VKFFNSNKK KRDDFEKLT NYSVTDLNV 
QRKAIHELI QVMAELSPA AKTGKRKRS 
QMLFRGRRA SQ

      Links to other resources

      UniProt P01579
      Ensembl ENST00000229135
      KEGG hsa:3458

      • Anatomical structure: cell_of_endometrium_of_uterus

        • Endometrial large granular lymphocytes (LGLs) produce interferon-g (IFN-g), particularly when interacting with macrophages or stimulated with interleukin 12 (IL-12) and IL-2. [4]

      • Anatomical structure: T-lymphocyte

        • In synergy with IFN-alpha or IL-12, IL-18 induces IFN-gamma production in T cells and enhances Th1 cell development. [5]

        Influenced by:

        • IL-18R
          in T-lymphocyte

      • Anatomical structure: killer_cell

        Influenced by:

        • IL-18R1
          in killer_cell
        • CD72
          in dendritic_cell_in_lymphoid_tissues
          • Activated NK cells express CD100 and produce soluble CD100. They interact with dendritic cells by several routs among which is the CD100-CD72 interaction. Such interaction lead to IFNgamma secretion which in turn activates other cells of the immune system. [6]
        • CD72
          in macrophage
          • Activated NK cells express CD100 and produce soluble CD100. They interact with macrophages by several routs among which is the CD100-CD72 interaction. Such interaction lead to IFNgamma secretion which in turn activates other cells of the immune system. [6]

      • Anatomical structure: peripheral blood mononuclear cell (PBMC)

      • Anatomical structure: helper_T_cell_Th1

        • Th1 cells mainly produce interferon-gamma, while Th2 cells selectively secrete IL-4 and IL-5. [7]

        Influenced by:

        • IL-18R
          in helper_T_cell_Th1
          • IL-18 is originally called interferon gamma inducing factor, due to its capacity to induce interferon gamma production in Th1 type cells. [8]

      • Anatomical structure: lung

      Targets

      CellIFNGR1IFNGR2
      monocyte Present
      Influences
      • ↑ CXCL11
      • ↑ IL-12
      • ↓ IL-10
      Reference