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Details for messenger / hormone: GM-CSF

EndoNet ID: ENH00266

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Synonyms

  • CSF2
  • GM-CSF
  • colony-stimulating factor
  • colony-stimulating factor-2
  • GMCSF
  • granulocyte-macrophage colony-stimulating factor
  • molgramostin
  • sargramostim

General information

  • GMCSF has a central role in proliferation and differentiation of hematopoetic cells. [1]
  • GMCSF influences the proliferation and migration of endothelial cells. [1]
  • Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. [2]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines

    Composition

    Sequence 
    APARSPSPS TQPWEHVNA IQEARRLLN 
LSRDTAAEM NETVEVISE MFDLQEPTC 
LQTRLELYK QGLRGSLTK LKGPLTMMA 
SHYKQHCPP TPETSCATQ IITFESFKE 
NLKDFLLVI PFDCWEPVQ E

    Links to other resources

    UniProt P04141
    Ensembl ENST00000296871
    KEGG hsa:1437

    • Anatomical structure: T-lymphocyte

      • Hematopoietic cytokines such as IL-3 and GM-CSF, produced by activated T cells and mast cells, are potent growth factors for various hematopoietic cells, as well as immature multipotential hematopoietic progenitors. [3]

    • Anatomical structure: continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

    • Anatomical structure: fibroblast

    • Anatomical structure: mast_cell

      • Hematopoietic cytokines such as interleukin 3 (IL-3) and granulocyte-macrophage colony stimulating factor (GM-CSF), produced by activated T cells and mast cells, are potent growth factors for various hematopoietic cells, as well as immature multipotential hematopoietic progenitors. [3]

    • Anatomical structure: bronchial_epithelial_cell

    • Anatomical structure: epithelial_cell_with_microvilli

    • Anatomical structure: propria_mucosa_of_bronchus

    Targets

    CellCSF2RBGM-CSFR
    dendritic cell in lymphoid tissues follicular Present
    eosinophil granulocyte Present
    hematopoietic stem cell Present
    Phenotypes
    • leukocyte production
    Reference