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Details for messenger / hormone: brain-derived neurotrophic factor

EndoNet ID: ENH00267

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Synonyms

  • BDNF isoform a
  • brain-derived neurotrophic factor
  • abrineurin

General information

  • Neurotrophic factor secreted by endothelial cells; promotes neuron maturation, survival, neurite outgrowth and migration. [1]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines

    Composition

    Sequence
    HSDPARRGE LSVCDSISE WVTAADKKT 
    AVDMSGGTV TVLEKVPVS KGQLKQYFY 
    ETKCNPMGY TKEGCRGID KRHWNSQCR 
    TTQSYVRAL TMDSKKRIG WRFIRIDTS 
    CVCTLTIKR GR

    Links to other resources

    UniProt P23560
    Ensembl ENST00000439476
    KEGG hsa:627
    • Anatomical structure: isocortex

      • The activation of the 5-HT-2B receptors increase the BDNF mRNA levels within regions of the neocortex. [2]
    • Anatomical structure: hippocampus

      • The activation of the 5-HT-2B receptor sybtypes decrease the BDNF mRNA levels within the dentate gyrus region of the hippocampus. [2]

    Targets

    CellNGF receptortrkB
    dorsal root ganglion Present
    Phenotypes
    • regulation of feeding behavior
    Reference