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Details for messenger / hormone: PDGF

EndoNet ID: ENH00270

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Synonyms

  • PDGF
  • platelet-derived growth factor
  • PDGF-AB

General information

  • PDGF acts as a potent mitogen, chemoattractant and survival factor for mesenchymal cells. [1]
  • PDGF is an homo- or heterodimeric protein, 2 homologous chains (A, B) are covalently bound via disulfide bonds.

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines

    Composition

    B chain

    Sequence 
    SLGSLTIAE PAMIAECKT RTEVFEISR 
RLIDRTNAN FLVWPPCVE VQRCSGCCN 
NRNVQCRPT QVQLRPVQV RKIEIVRKK 
PIFKKATVT LEDHLACKC ETVAAARPV 
T
    UniProt P01127

    A chain

    Sequence 
    SIEEAVPAV CKTRTVIYE IPRSQVDPT 
SANFLIWPP CVEVKRCTG CCNTSSVKC 
QPSRVHHRS VKVAKVEYV RKKPKLKEV 
QVRLEEHLE CACATTSLN PDYREEDTG 
RPRESGKKR KRKRLKPT
    UniProt P04085

    Links to other resources

      Targets

      CellPDGFR
      lipocyte of liver Present
      Phenotypes
      • regulation of tissue remodeling
      Reference