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Details for messenger / hormone: PlGF-3

EndoNet ID: ENH00272

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Synonyms

  • PlGF
  • placenta growth factor
  • PGF
  • PLGF
  • placental growth factor
  • PlGF-3

General information

  • Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration. [1]
  • Placental growth factor is up-regulated in early and advanced atherosclerotic lesions, acts as a primary inflammatory instigator of atherosclerotic plaque instability, and may be an independent biomarker of adverse outcome in patients with acute coronary syndromes. [2]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • PDGF/VEGF growth factor family

      Composition

      Sequence 
      LPAVPPQQW ALSAGNGSS EVEVVPFQE 
VWGRSYCRA LERLVDVVS EYPSEVEHM 
FSPSCVSLL RCTGCCGDE NLHCVPVET 
ANVTMQLLK IRSGDRPSY VELTFSQHV 
RCECRHSPG RQSPDMPGD FRADAPSFL 
PPRRSLPML FRMEWGCAL TGSQSAVWP 
SSPVPEEIP RMHPGRNGK KQQRKPLRE 
KMKPERCGD AVPRR
      UniProt P49763-1

      Links to other resources

      UniProt P49763
      Ensembl ENST00000405431
      KEGG hsa:5228

      • Anatomical structure: placenta

      • Anatomical structure: trophoblast_cell

      Targets

      CellsVEGF-R1Vascular endothelial growth factor receptor 1
      bone marrow Present
      Phenotypes
      • hematopoiesis
      brain Present
      		Present
      continuous vascular endothelial cell of blood vessels and lymphatics Present
      Phenotypes
      • regulation of angiogenesis
      • positive regulation of endothelial cell proliferation
      • positive regulation of endothelial cell migration
      • inflammation
      Influences
      • ↑ interleukin 6
      heart Present
      		Present
      Phenotypes
      • heart development
      kidney Present
      		Present
      lung Present
      		Present
      Müllers radial cell of retina Present
      Phenotypes
      • regulation of neural retina development
      placenta Present
      		Present
      Phenotypes
      • preeclampsia
      sinusoidal endothelial cell Present
      Phenotypes
      • negative regulation of apoptosis
      smooth muscle Present
      Phenotypes
      • vessel maturation
      vascularendothelial cell Present
      		Present
      Phenotypes
      • vasculogenesis
      • vascular permeability
      Reference