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Details for messenger / hormone: IL-18

EndoNet ID: ENH00273

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Synonyms

  • Iboctadekin
  • Interleukin-18
  • IL-18
  • IL18
  • IL 18
  • interleukin 18
  • interferon-gamma-inducing factor
  • IFN-gamma-inducing factor
  • interleukin-1 gamma
  • IL-1 gamma
  • IGIF

General information

  • IL-18 enhances collagen-induced arthritis by recruiting neutrophils via TNF-alpha and leukotriene B4. [1]
  • IL-18 is expressed by a wide variety of cell types including mononuclear phagocytes, osteoblasts, keratinocytes and adrenal cortex cells. [2]
  • IL-18 induction is a useful target in immunotherapy of allergic disease. [3]
  • Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T helper type I cells. [4]
  • IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells. [5]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines

    Composition

    Sequence
    YFGKLESKL SVIRNLNDQ VLFIDQGNR 
    PLFEDMTDS DCRDNAPRT IFIISMYKD 
    SQPRGMAVT ISVKCEKIS TLSCENKII 
    SFKEMNPPD NIKDTKSDI IFFQRSVPG 
    HDNKMQFES SSYEGYFLA CEKERDLFK 
    LILKKEDEL GDRSIMFTV QNED

    Links to other resources

    UniProt Q14116
    Ensembl ENST00000280357
    KEGG hsa:3606
    • Anatomical structure: continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

    • Anatomical structure: macrophage

    • Anatomical structure: mucosa_of_small_intestine

      • IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells. [5]
    • Anatomical structure: epithelial_cell

    • Anatomical structure: dendritic_cell_in_lymphoid_tissues

    • Anatomical structure: distal_tubule_of_nephron

    • Anatomical structure: leukocyte

    • Anatomical structure: kidney

      • Upregulation of epithelial IL-18 plays an important role in immune and immunopathological reactions in renal parenchyma and contributes to rejection mechanisms of kidney allograft. [6]
    • Anatomical structure: smooth_muscle_cell

      • Angiotensin II enhances interleukin-18 mediated inflammatory gene expression in vascular smooth muscle cells. [7]
    • Anatomical structure: osteoblast

    • Anatomical structure: keratinocyte

    • Anatomical structure: adrenal_cortex

    • Anatomical structure: monocyte

    • Anatomical structure: Kupffer_cell_stellate_cell_of_liver

      • IL-18 acts on natural killer cells to increase Fas ligand (FasL) that causes liver injury by induction of Fas-dependent hepatocyte apoptosis. [8]
      • Kupffer cells have the potential to induce liver injury by production of IL- 18. [8]

      Influenced by:

      • TLR4
        in Kupffer_cell_stellate_cell_of_liver
        • LPS induces IL-18 secretion from Kupffer cells in a caspase-1-dependent manner. [8]

    Targets

    CellIL-18RIL-18R1
    B-lymphocyte Present
    colon Present
    heart Present
    helper T cell Th1 Present
    Influences
    • IFN-gamma
    Present
    killer cell Present
    Influences
    • IFN-gamma
    leukocyte Present
    lung Present
    placenta Present
    prostate Present
    small intestine Present
    spleen Present
    T-lymphocyte Present
    Influences
    • IFN-gamma
    Present
    thymus Present
    Reference