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Details for messenger / hormone: PlGF-2

EndoNet ID: ENH00274

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Synonyms

  • placenta growth factor 2
  • placenta growth factor
  • PlGF-2
  • PlGF-152

General information

  • The heparin-blocking peptide of PlGF-2 and its receptor Flt-1 reduces the growth and metastasis of human breast cancer xenografts. [1]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • PDGF/VEGF growth factor family

      Composition

      Sequence
      LPAVPPQQW ALSAGNGSS EVEVVPFQE 
      VWGRSYCRA LERLVDVVS EYPSEVEHM 
      FSPSCVSLL RCTGCCGDE NLHCVPVET 
      ANVTMQLLK IRSGDRPSY VELTFSQHV 
      RCECRPLRE KMKPERRRP KGRGKRRRE 
      KQRPTDCHL CGDAVPRR

      Links to other resources

      UniProt P49763-3
      Ensembl ENST00000405431
      KEGG hsa:5228
      • Anatomical structure: placenta

        • While the three forms are present in most placental tissues, the PlGF-2 is specific to early (8 week) placenta. [2]
      • Anatomical structure: trophoblast_cell

      • Anatomical structure: umbilical_vein_endothelial_cells

      Targets

      Cellneuropilin 1neuropilin-2Vascular endothelial growth factor receptor 1
      blood vessel Present
      Phenotypes
      • excess of capillary formation
      • patterning of blood vessels
      bone marrow Present
      Present
      Phenotypes
      • hematopoiesis
      brain Present
      Phenotypes
      • axon guidance
      Present
      continuous vascular endothelial cell of blood vessels and lymphatics Present
      Phenotypes
      • regulation of angiogenesis
      • positive regulation of endothelial cell proliferation
      • positive regulation of endothelial cell migration
      • inflammation
      Influences
      • interleukin 6
      glomerulus Present
      Phenotypes
      • induction of podocyte apoptosis
      • formation of glomerular filter barrier
      • inhibition of glomerular capillary lumen development
      • patterning of blood vessels
      • positive regulation of apoptosis
      heart Present
      Phenotypes
      • patterning of blood vessels
      Present
      Phenotypes
      • heart development
      kidney Present
      Phenotypes
      • inhibition of ureteric bud branching
      • excess of endothelial cells
      • podocyte differentiation
      • cell differentiation
      • acute nephrotic range proteinuria
      Present
      lung Present
      Present
      mammary gland Present
      Müllers radial cell of retina Present
      Phenotypes
      • regulation of neural retina development
      neuron Present
      Phenotypes
      • axon guidance
      pancreas Present
      placenta Present
      Present
      Phenotypes
      • preeclampsia
      podocyte Present
      Present
      sinusoidal endothelial cell Present
      Phenotypes
      • negative regulation of apoptosis
      skeleton muscle Present
      smooth muscle Present
      Phenotypes
      • vessel maturation
      vascularendothelial cell Present
      Phenotypes
      • regulation of angiogenesis
      Present
      Phenotypes
      • vasculogenesis
      • vascular permeability
      Reference