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Details for messenger / hormone: RANTES

EndoNet ID: ENH00276

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Synonyms

  • EoCP
  • eosinophil-chemotactic cytokine
  • T-cell-specific protein RANTES
  • small-inducible cytokine A5
  • C-C motif chemokine 5
  • regulated upon Activation, Normally T-Expressed, and presumably Secreted
  • RANTES
  • CCL5
  • small inducible cytokine A5
  • T-cell-specific RANTES protein
  • SIS-delta
  • T cell-specific protein P228
  • TCP228
  • chemokine, CC motif, Ligand 5
  • SCYA5

General information

  • Chemoattractant for blood monocytes, memory T helper cells and eosinophils.

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • chemokines
            • CC chemokines

      Links to other resources

      UniProt P13501
      Ensembl ENST00000366113
      KEGG hsa:6352
      • Anatomical structure: astrocyte

        • RANTES promotes growth and survival of human first-trimester forebrain astrocytes. [1]
      • Anatomical structure: vascularendothelial_cell

      • Anatomical structure: Kupffer_cell_stellate_cell_of_liver

        • Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. [3]
      • Anatomical structure: hepatocyte

      • Anatomical structure: lipocyte_of_liver

        • Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. [3]
        • RANTES is elevated in patients with alcoholic hepatitis or chronic hepatitis C. [3]

        Influenced by:

        • CD40
          in lipocyte_of_liver
          • RANTES mRNA and protein secretion were strongly induced after stimulating HSCs with TNF-alpha, IL-1beta, or CD40L. [3]
        • TNFR1
          in lipocyte_of_liver
          • Hepatic stellate cells secrete RANTES after stimulation with TNF-alpha, IL-1beta, and CD40L in an inhibitor-kappaB (I kappa B)kinase (IKK)2/NF kappaB- and JNK-dependent manner. [3]
        • TNFR2
          in lipocyte_of_liver
          • Hepatic stellate cells secrete RANTES after stimulation with TNF-alpha, IL-1beta, and CD40L in an inhibitor-kappaB (I kappa B)kinase (IKK)2/NF kappaB- and JNK-dependent manner. [3]
        • IL-1RI
          in lipocyte_of_liver
          • Hepatic stellate cells secrete RANTES after stimulation with TNF-alpha, IL-1beta, and CD40L in an inhibitor-kappaB (I kappa B)kinase (IKK)2/NF kappaB- and JNK-dependent manner. [3]
        • IL-1RII
          in lipocyte_of_liver
          • Hepatic stellate cells secrete RANTES after stimulation with TNF-alpha, IL-1beta, and CD40L in an inhibitor-kappaB (I kappa B)kinase (IKK)2/NF kappaB- and JNK-dependent manner. [3]
        • CCR5
          in lipocyte_of_liver
          • Hepatic stellate cell derived RANTES acts on hepatic stellate cells in an autocrine fashion. [3]
          • Activated hepatic stellate cells express CCR5 and respond to recombinant human (rh)RANTES stimulation with an increase in proliferation and migration in a CCR5-dependent manner. [3]
          • Even under inflammatory conditions, RANTES would exert biological effects in a paracrine rather than an autocrine fashion. [3]
      • Anatomical structure: dendritic_cell_in_lymphoid_tissues

      • Anatomical structure: macrophage

      Targets

      CellCCR1CCR3CCR5D6
      eosinophil granulocyte Present
      epithelial cell with microvilli Present
      lipocyte of liver Present
      Phenotypes
      • hepatic stellate cell migration
      • ERK activation
      • positive regulation of cell proliferation
      Influences
      • RANTES
      lung Present
      lymph node Present
      monocyte Present
      Present
      Present
      neutrophil granulocyte Present
      Reference