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Details for messenger / hormone: ENA-78

EndoNet ID: ENH00277

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Synonyms

  • ENA-78
  • ENA-78(1-78)
  • small-inducible cytokine B5
  • C-X-C motif chemokine 5
  • ENA78
  • ENA 78
  • small inducible cytokine B5
  • LIX
  • CXCL5
  • SCYB5
  • epithelial-derived neutrophil-activating protein 78
  • neutrophil-activating peptide ENA-78

General information

  • ENA78 is an inflammatory chemokine which is produced concomitantly with interleukin-8 (IL-8) in response to stimulation with either interleukin-1 (IL-1 beta) or tumor necrosis factor-alpha (TNF-alpha). [1]
  • CXC chemokine, acts as a potent chemoattractant and activator of neutrophil function, is highly expressed in many cell types. [2]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • chemokines
            • CXC chemokines

      Composition

      Sequence 
      AGPAAAVLR ELRCVCLQT TQGVHPKMI 
SNLQVFAIG PQCSKVEVV ASLKNGKEI 
CLDPEAPFL KKVIQKILD GGNKEN

      Links to other resources

      UniProt P42830
      Ensembl ENST00000296027
      KEGG hsa:6374

      • Anatomical structure: mucosa_of_small_intestine

      • Anatomical structure: continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

      • Anatomical structure: epithelial_cell

      • Anatomical structure: monocyte

      • Anatomical structure: eosinophil_granulocyte

      • Anatomical structure: neutrophil_granulocyte

      • Anatomical structure: epithelial_cell_with_microvilli

      Targets

      CellCXCR1IL-8R B
      acidophil mammotroph cell of anterior pituitary Present
      Influences
      • ↑ PRL
      acidophil somatotroph cell of anterior pituitary Present
      Influences
      • ↑ GH
      basophil corticotroph cell of anterior pituitary Present
      Influences
      • ↑ ACTH
      basophil gonadotroph cell of anterior pituitary FSH Present
      Influences
      • ↓ FSH
      • ↓ LH
      basophil thyrotroph cell of anterior pituitary Present
      killer cell Present
      		Present
      monocyte Present
      		Present
      neutrophil granulocyte Present
      		Present
      Reference