Status
Please wait ...

Details for messenger / hormone: GROalpha

EndoNet ID: ENH00279

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be:

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • SCYB1
  • GRO alpha
  • GRO-alpha(1-73)
  • C-X-C motif chemokine 1
  • growth-regulated alpha protein
  • CXCL1
  • GROalpha
  • NAP-3
  • neutrophil-activating protein 3
  • growth regulated protein alpha
  • GRO1
  • small inducible cytokine B1
  • GROA
  • Gro-alpha
  • chemokine, CXC Motif, Ligand 1
  • GRO1 oncogene
  • growth related oncogene alpha
  • MGSA
  • melanoma growth stimulatory activity

General information

  • GROalpha is a secreted interleukin-like molecule that interacts with the CXCR2 G-protein-coupled receptor. [1]
  • GROalpha is highly expressed in adenocarcinoma of the colon and down-regulates fibulin-1. [1]
  • Expression of the cytokine gene gro, also known as melanoma growth stimulatory activity, is induced by inflammatory stimuli, including IL-1. [2]
  • Endothelin-1 induces CXCL1 and CXCL8 secretion in human melanoma cells. [3]
  • The constitutive expression of CXCL1 and its receptor CXCR2 is associated with metastatic potential and modulates colon cancer cell proliferation and an invasive phenotype. [4]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • chemokines
            • CXC chemokines

      Composition

      Sequence
      ASVATELRC QCLQTLQGI HPKNIQSVN 
      VKSPGPHCA QTEVIATLK NGRKACLNP 
      ASPIVKKII EKMLNSDKS N

      Links to other resources

      UniProt P09341
      Ensembl ENST00000395761
      KEGG hsa:2919
      • Anatomical structure: epithelial_cell

      • Anatomical structure: fibroblast

      • Anatomical structure: melanocyte

      • Anatomical structure: colon

      • Anatomical structure: leukocyte

      • Anatomical structure: bronchi

        • The bronchial epithelium is a source not only for the C-X-C chemokines interleukin-8 and GRO-alpha, but also for the neutrophil chemoattractant granulocyte chemotactic protein (GCP)-2. [5]

        Influenced by:

        • IL-17R
          in bronchi
          • Compared to baseline (inherent) release, the peak response of interleukin-17-induced release of GRO-alpha was 259% (+/-12%). [5]
      • Anatomical structure: hepatocyte

      • Anatomical structure: bronchial_epithelial_cell

      • Anatomical structure: epithelial_cell_with_microvilli

      Targets

      CellCXCR1IL-8R B
      acidophil mammotroph cell of anterior pituitary Present
      Influences
      • PRL
      acidophil somatotroph cell of anterior pituitary Present
      Influences
      • GH
      basophil corticotroph cell of anterior pituitary Present
      Influences
      • ACTH
      basophil gonadotroph cell of anterior pituitary FSH Present
      Influences
      • FSH
      • LH
      basophil thyrotroph cell of anterior pituitary Present
      killer cell Present
      Present
      monocyte Present
      Present
      neutrophil granulocyte Present
      Present
      Reference