Status
Please wait ...

Details for messenger / hormone: MSP

EndoNet ID: ENH00281

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be:

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • macrophage-stimulating protein
  • MST1
  • MSP
  • macrophage stimulatory protein
  • D3F15S2
  • DNF15S2
  • hepatocyte growth factor-like protein
  • HGFL
  • macrophage stimulating protein
  • NF15S2

General information

  • Dimer of an alpha chain and a beta chain linked by a disulfide bond. [1]
  • Function: Ligand for the receptor tyrosine kinase RON, thus contributing in the processes of: wound healing, epithelial cell behaviour, and tumor growth. [2]

Classification

Hormone function

  • development and growth
    • cancer / metastasis
    • immune response
      • activation

      Chemical classification

      • hormone
        • genome-encoded
          • cytokines

      Composition

      HGFL alpha chain (1 times)

      Sequence
      QRSPLNDFQ VLRGTELQH LLHAVVPGP 
      WQEDVADAE ECAGRCGPL MDCRAFHYN 
      VSSHGCQLL PWTQHSPHT RLRRSGRCD 
      LFQKKDYVR TCIMNNGVG YRGTMATTV 
      GGLPCQAWS HKFPNDHKY TPTLRNGLE 
      ENFCRNPDG DPGGPWCYT TDPAVRFQS 
      CGIKSCREA ACVWCNGEE YRGAVDRTE 
      SGRECQRWD LQHPHQHPF EPGKFLDQG 
      LDDNYCRNP DGSERPWCY TTDPQIERE 
      FCDLPRCGS EAQPRQEAT TVSCFRGKG 
      EGYRGTANT TTAGVPCQR WDAQIPHQH 
      RFTPEKYAC KDLRENFCR NPDGSEAPW 
      CFTLRPGMR AAFCYQIRR CTDDVRPQD 
      CYHGAGEQY RGTVSKTRK GVQCQRWSA 
      ETPHKPQFT FTSEPHAQL EENFCRNPD 
      GDSHGPWCY TMDPRTPFD YCALRRCAD 
      DQPPSILDP PDQVQFEKC GKRVDRLDQ 
      RRS

      HGFL beta chain (1 times)

      Sequence
      VVGGHPGNS PWTVSLRNR QGQHFCGGS 
      LVKEQWILT ARQCFSSCH MPLTGYEVW 
      LGTLFQNPQ HGEPSLQRV PVAKMVCGP 
      SGSQLVLLK LERSVTLNQ RVALICLPP 
      EWYVVPPGT KCEIAGWGE TKGTGNDTV 
      LNVALLNVI SNQECNIKH RGRVRESEM 
      CTEGLLAPV GACEGDYGG PLACFTHNC 
      WVLEGIIIP NRVCARSRW PAVFTRVSV 
      FVDWIHKVM RLG

      Links to other resources

      UniProt P26927
      Ensembl ENST00000383728
      KEGG hsa:4485
      • Anatomical structure: liver

        • Hepatocyte growth factor-like protein (HGFL) is a liver-derived serum glycoprotein. [3]

      Targets

      Cellmacrophage-stimulating protein receptor
      keratinocyte Present
      Phenotypes
      • wound healing
      monocyte Present
      Reference