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Details for messenger / hormone: GRObeta

EndoNet ID: ENH00282

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Synonyms

  • hematopoietic synergistic factor
  • SB-251353
  • GRO-beta-T
  • growth-regulated protein beta
  • C-X-C motif chemokine 2
  • GRObeta
  • growth related oncogen beta
  • CXCL2
  • chemokine, CXC Motif, Ligand 2
  • small inducible cytokine B2
  • GRO2
  • GRO2 oncogene
  • macrophage inflammatory protein 2
  • MIP2
  • GRO protein beta
  • GROB
  • macrophage inflammatory protein 2-alpha

General information

  • Produced by activated monocytes and neutrophils and expressed at sites of inflammation.
  • Cytokine with inflammatory and growth-regulatory properties. [1]
  • Potent chemotactic agent for human polymorphonuclear leukocytes. [2]
  • Expression of the cytokine gene gro, also known as melanoma growth stimulatory activity, is induced by inflammatory stimuli, including IL-1. [3]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • chemokines
            • CXC chemokines

      Composition

      Sequence 
      APLATELRC QCLQTLQGI HLKNIQSVK 
VKSPGPHCA QTEVIATLK NGQKACLNP 
ASPMVKKII EKMLKNGKS N

      Links to other resources

      UniProt P19875
      Ensembl ENST00000264492
      KEGG hsa:2920

      • Anatomical structure: monocyte

      • Anatomical structure: neutrophil_granulocyte

      • Anatomical structure: macrophage

      • Anatomical structure: hepatocyte

      • Anatomical structure: lipocyte_of_liver

        • HSCs produce a variety of chemokines including macrophage inflammatory protein-2 (MIP-2, GRObeta). [4]

      • Anatomical structure: bronchial_epithelial_cell

      • Anatomical structure: epithelial_cell_with_microvilli

      Targets

      CellCXCR1IL-8R B
      acidophil mammotroph cell of anterior pituitary Present
      Influences
      • ↑ PRL
      acidophil somatotroph cell of anterior pituitary Present
      Influences
      • ↑ GH
      basophil corticotroph cell of anterior pituitary Present
      Influences
      • ↑ ACTH
      basophil gonadotroph cell of anterior pituitary FSH Present
      Influences
      • ↓ FSH
      • ↓ LH
      basophil thyrotroph cell of anterior pituitary Present
      killer cell Present
      		Present
      monocyte Present
      		Present
      neutrophil granulocyte Present
      		Present
      Reference