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Details for messenger / hormone: GAS-6

EndoNet ID: ENH00283

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Synonyms

  • AXL receptor tyrosine kinase ligand
  • GAS-6
  • growth arrest-specific protein 6

General information

  • The Akt/mTOR pathway is a key signaling cascade in Gas6-mediated mesangial and glomerular hypertrophy. [1]
  • GAS-6 regulates chondrogenic differentiation negatively. [2]

Classification

Hormone function

  • development and growth
    • growth inhibition

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines

    Composition

    Sequence 
    ALLPAREAT QFLRPRQRR AFQVFEEAK 
QGHLERECV EELCSREEA REVFENDPE 
TDYFYPRYL DCINKYGSP YTKNSGFAT 
CVQNLPDQC TPNPCDRKG TQACQDLMG 
NFFCLCKAG WGGRLCDKD VNECSQENG 
GCLQICHNK PGSFHCSCH SGFELSSDG 
RTCQDIDEC ADSEACGEA RCKNLPGSY 
SCLCDEGFA YSSQEKACR DVDECLQGR 
CEQVCVNSP GSYTCHCDG RGGLKLSQD 
MDTCELEAG WPCPRHRRD GSPAARPGR 
GAQGSRSEG HIPDRRGPR PWQDILPCV 
PFSVAKSVK SLYLGRMFS GTPVIRLRF 
KRLQPTRLV AEFDFRTFD PEGILLFAG 
GHQDSTWIV LALRAGRLE LQLRYNGVG 
RVTSSGPVI NHGMWQTIS VEELARNLV 
IKVNRDAVM KIAVAGDLF QPERGLYHL 
NLTVGGIPF HEKDLVQPI NPRLDGCMR 
SWNWLNGED TTIQETVKV NTRMQCFSV 
TERGSFYPG SGFAFYSLD YMRTPLDVG 
TESTWEVEV VAHIRPAAD TGVLFALWA 
PDLRAVPLS VALVDYHST KKLKKQLVV 
LAVEHTALA LMEIKVCDG QEHVVTVSL 
RDGEATLEV DGTRGQSEV SAAQLQERL 
AVLERHLRS PVLTFAGGL PDVPVTSAP 
VTAFYRGCM TLEVNRRLL DLDEAAYKH 
SDITAHSCP PVEPAAA

    Links to other resources

    UniProt Q14393
    Ensembl ENST00000357389
    KEGG hsa:2621

    • Anatomical structure: spleen

      • Isoform 1 is the predominant form in spleen. [3]

    Targets

    CellAXLc-MerTyro-3
    No records found.
    Reference