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Details for messenger / hormone: ANG-1

EndoNet ID: ENH00284

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Synonyms

  • Angiopoietin-1
  • ANG-1
  • angiopoietin 1
  • ANGPT1
  • KIAA0003

General information

  • Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development. [1]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines

    Composition

    Sequence 
    HIGCSNQRR SPENSGRRY NRIQHGQCA 
YTFILPEHD GNCRESTTD QYNTNALQR 
DAPHVEPDF SSQKLQHLE HVMENYTQW 
LQKLENYIV ENMKSEMAQ IQQNAVQNH 
TATMLEIGT SLLSQTAEQ TRKLTDVET 
QVLNQTSRL EIQLLENSL STYKLEKQL 
LQQTNEILK IHEKNSLLE HKILEMEGK 
HKEELDTLK EEKENLQGL VTRQTYIIQ 
ELEKQLNRA TTNNSVLQK QQLELMDTV 
HNLVNLCTK EGVLLKGGK REEEKPFRD 
CADVYQAGF NKSGIYTIY INNMPEPKK 
VFCNMDVNG GGWTVIQHR EDGSLDFQR 
GWKEYKMGF GNPSGEYWL GNEFIFAIT 
SQRQYMLRI ELMDWEGNR AYSQYDRFH 
IGNEKQNYR LYLKGHTGT AGKQSSLIL 
HGADFSTKD ADNDNCMCK CALMLTGGW 
WFDACGPSN LNGMFYTAG QNHGKLNGI 
KWHYFKGPS YSLRSTTMM IRPLDF

    Links to other resources

    UniProt Q15389
    Ensembl ENST00000297450
    KEGG hsa:284

      Targets

      Reference