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Details for messenger / hormone: ANG-2

EndoNet ID: ENH00285

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Synonyms

  • ANG-2
  • angiopoietin 2
  • angiopoietin-2
  • ANGPT2

General information

  • ANG-2 destabilizes vascular endothelium and increases vascular leakage. [1]
  • ANG-2 represents an independent prognostic factor in acute myeloid leukemia. [2]
  • In the absence of angiogenic inducers, such as VEGF, ANG2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. [3]

Classification

Hormone function

  • development and growth
    • growth stimulation
      • growth inhibition

      Chemical classification

      • hormone
        • genome-encoded
          • cytokines

      Composition

      Sequence 
      AAYNNFRKS MDSIGKKQY QVQHGSCSY 
TFLLPEMDN CRSSSSPYV SNAVQRDAP 
LEYDDSVQR LQVLENIME NNTQWLMKL 
ENYIQDNMK KEMVEIQQN AVQNQTAVM 
IEIGTNLLN QTAEQTRKL TDVEAQVLN 
QTTRLELQL LEHSLSTNK LEKQILDQT 
SEINKLQDK NSFLEKKVL AMEDKHIIQ 
LQSIKEEKD QLQVLVSKQ NSIIEELEK 
KIVTATVNN SVLQKQQHD LMETVNNLL 
TMMSTSNSA KDPTVAKEE QISFRDCAE 
VFKSGHTTN GIYTLTFPN STEEIKAYC 
DMEAGGGGW TIIQRREDG SVDFQRTWK 
EYKVGFGNP SGEYWLGNE FVSQLTNQQ 
RYVLKIHLK DWEGNEAYS LYEHFYLSS 
EELNYRIHL KGLTGTAGK ISSISQPGN 
DFSTKDGDN DKCICKCSQ MLTGGWWFD 
ACGPSNLNG MYYPQRQNT NKFNGIKWY 
YWKGSGYSL KATTMMIRP ADF

      Links to other resources

      UniProt O15123
      Ensembl ENST00000325203
      KEGG hsa:285

      • Anatomical structure: fat_cell

        Influenced by:

        • leptin receptor isoform b
          in fat_cell
          • Leptin induces Ang-2 and no VEGF in cultured adipocytes. [4]

      Targets

      Reference