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Details for messenger / hormone: VCAM1 soluble form

EndoNet ID: ENH00287

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Synonyms

  • VCAM1 soluble form
  • VCAM-1
  • VCAM 1
  • vascular cell adhesion protein 1
  • V-CAM 1
  • CD106 antigen
  • INCAM-100
  • vascular cell adhesion molecule 1
  • soluble VCAM-1
  • sVCAM-1

General information

  • Important in cell-cell recognition.
  • Increased expression of VCAM1 is associated with a variety of chronic inflammatory conditions, making its expression and function a target for therapeutic intervention. [1]
  • Leptin upregulates endothelin 1, VCAM1 and MCP1. [2]
  • The interaction between VCAM1 and VLA4 (integrin very late antigen-4) plays an important role in inflammatory and immune responses in vivo. [3]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • immunoglobulin superfamily

      Links to other resources

      UniProt P19320
      Ensembl ENST00000294728
      KEGG hsa:7412

      • Anatomical structure: vascularendothelial_cell

      • Anatomical structure: continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

      • Anatomical structure: sinusoidal_endothelial_cell

      • Anatomical structure: propria_mucosa_of_bronchus

      • Anatomical structure: aorta

      • Anatomical structure: artery

      • Anatomical structure: blood_vessel

      • Anatomical structure: microvascularendothelial_cell

      • Anatomical structure: brain

      • Anatomical structure: decidua

      • Anatomical structure: cell_of_endometrium_of_uterus

      • Anatomical structure: smooth_muscle

      • Anatomical structure: renal_cortex

      • Anatomical structure: lung

      • Anatomical structure: propria_mucosa_of_bronchus

      • Anatomical structure: respiratory_organ

      • Anatomical structure: retina

      • Anatomical structure: serum

      • Anatomical structure: skin

      • Anatomical structure: umbilical_cord

      • Anatomical structure: umbilical_vein_endothelial_cells

      • Anatomical structure: neutrophil_granulocyte

      • Anatomical structure: right_coronary_artery

      • Anatomical structure: left coronary artery

      Targets

      Cellintegrin alpha-9/beta-1
      No records found.
      Reference