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Details for messenger / hormone: IL-7

EndoNet ID: ENH00288

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Synonyms

  • Interleukin-7
  • IL-7
  • IL7
  • interleukin 7

General information

  • Interleukin-7 stimulates osteoclastogenesis by inducing TNF-alpha release by T and B cells. [1]
  • Interleukin-7 supports osteoclastogenesis formation by inducing the TNF-alpha(tumour necrosis factor-alpha) production and low RANKL(receptor activator of NF-kappaB ligand) levels. [2]
  • Interleukin-7 induces TNF-alpha secretion by T cells and by monocytes after T cell dependent monocyte/macrophage activation. [3]
  • MIL-7(murine interleukin-7 ) affects human lymphocytes, that indicates mouse models of human lymphoid development and disease must integrate the biological effects of endogenous IL-7 on human cells. [4]
  • Interleukin 7 is a crucial factor for the development of murine T and B lymphocytes. [5]
  • Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes. [6]

Classification

Hormone function

  • development and growth
    • environment adaptation
    • immune response
      • activation

      Chemical classification

      • hormone
        • genome-encoded
          • cytokines

      Composition

      Sequence
      DCDIEGKDG KQYESVLMV SIDQLLDSM 
      KEIGSNCLN NEFNFFKRH ICDANKEGM 
      FLFRAARKL RQFLKMNST GDFDLHLLK 
      VSEGTTILL NCTGQVKGR KPAALGEAQ 
      PTKSLEENK SLKEQKKLN DLCFLKRLL 
      QEIKTCWNK ILMGTKEH

      Links to other resources

      UniProt P13232
      Ensembl ENST00000263851
      KEGG hsa:3574
      • Anatomical structure: epithelial_cell

      • Anatomical structure: hepatocyte

      • Anatomical structure: mucosa_of_small_intestine

        • Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes. [6]
      • Anatomical structure: lymphocyte

      • Anatomical structure: bone_marrow

      Targets

      CellIL-7Ralpha
      No records found.
      Reference