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Details for messenger / hormone: TFF1

EndoNet ID: ENH00290

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Synonyms

  • BCEI PS2
  • polypeptide P1.A
  • protein pS2
  • TFF1
  • trefoil factor 1
  • breast cancer estrogen-inducible protein
  • HP1.A
  • PNR-2
  • pS2 protein
  • TFF-1

General information

  • Is also expressed in breast cancer but not in normal tissue. It is regulated by estrogen in MCF-7 cells. [1]
  • Expressed in a number of carcinomas including breast (50%), pancreas (70-75%), stomach (50-55%), and large bowel (58%). [1]
  • Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. [1]
  • Functions: gastric tumor suppressor, limits cell proliferation and apoptosis, fasvors cell differentiation [2]

Classification

Hormone function

  • development and growth
    • cancer / metastasis
      • growth stimulation
        • growth inhibition
          • apoptosis

          Chemical classification

          • hormone
            • genome-encoded
              • growth hormones

            Composition

            Sequence 
            EAQTETCTV APRERQNCG FPGVTPSQC 
ANKGCCFDD TVRGVPWCF YPNTIDVPP 
EEECEF

            Links to other resources

            UniProt P04155
            Ensembl ENST00000291527
            KEGG hsa:7031

            • Anatomical structure: stomach

              • Found in stomach [1]

            • Anatomical structure: mucosa_of_gastric_wall

              • Strong expression found in normal gastric mucosa and in the regenerative tissues surrounding ulcerous lesions of gastrointestinal tract. [1]

            • Anatomical structure: endodermal_epithelium_of_stomach

              • TFF-1 is expressed by gastric epithelial cells that are not thought to express the CCK-2 receptor. [3]

            Targets

            Cell
            No records found.
            Reference