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Details for messenger / hormone: FGF-6

EndoNet ID: ENH00296

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Synonyms

  • FGF-6
  • FGF6
  • fibroblast growth factor 6
  • HST2
  • HBGF-6
  • heparin-binding growth factor 6
  • HST-2

General information

  • Can transform NIH 3T3 cells. Exhibits strong mitogenic and angiogenic properties. [1]
  • The effects of FGF-6 on fiber type are independent of the neuron source used for reinnervation. [2]
  • Involved in skeletal muscle development.
  • FGF-6 plays an important role in the muscle regeneration by stimulating or activating satellite cells. [3]
  • Deficiency of FGF-6 increases in type I fibers in muscles reinnervated from peripheral axons,the effects of FGF-6 on fiber type are independent of the neuron source used for reinnervation. [4]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • heparin-binding growth factors

      Composition

      Sequence
      SPAGTRANN TLLDSRGWG TLLSRSRAG 
      LAGEIAGVN WESGYLVGI KRQRRLYCN 
      VGIGFHLQV LPDGRISGT HEENPYSLL 
      EISTVERGV VSLFGVRSA LFVAMNSKG 
      RLYATPSFQ EECKFRETL LPNNYNAYE 
      SDLYQGTYI ALSKYGRVK RGSKVSPIM 
      TVTHFLPRI

      Links to other resources

      UniProt P10767
      Ensembl ENST00000228837
      KEGG hsa:2251

        Targets

        CellFGFR-4
        hepatocyte Present
        Reference