Status
Please wait ...

Details for messenger / hormone: FGF-7

EndoNet ID: ENH00297

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be:

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • FGF7
  • FGF-7
  • fibroblast growth factor 7
  • HBGF-7
  • keratinocyte growth factor
  • KGF
  • heparin-binding growth factor 7

General information

  • Involved in kidney and lung development, angiogenesis, and wound healing.
  • FGF-7 modulates the extent of ureteric bud growth during development and the number of nephrons that eventually form in the kidney. [1]
  • Studies on KGF show that this factor is progesterone dependent and contributes to myofibroblast cell growth. [2]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • heparin-binding growth factors

      Composition

      Sequence
      CNDMTPEQM ATNVNCSSP ERHTRSYDY 
      MEGGDIRVR RLFCRTQWY LRIDKRGKV 
      KGTQEMKNN YNIMEIRTV AVGIVAIKG 
      VESEFYLAM NKEGKLYAK KECNEDCNF 
      KELILENHY NTYASAKWT HNGGEMFVA 
      LNQKGIPVR GKKTKKEQK TAHFLPMAI 
      T

      Links to other resources

      UniProt P21781
      Ensembl ENST00000267843
      KEGG hsa:2252
      • Anatomical structure: fibroblast

        Influenced by:

        • ER-beta
          in fibroblast
          • ER-beta variants, including ER-beta 1, ER-beta 2, ER-beta 5, ER-betadelta and ER-betains, but not ER-alpha, are expressed in human adult mammary fibroblasts. An ER-beta-selective ligand, BAG, but not the ER-alpha high-affinity ligand oestradiol, can induce fibroblast growth factor-7 release in adult human mammary fibroblasts. [3]

      Targets

      CellFGF-BPFGFR-2
      adrenal cortex Present
      cardiac muscle Present
      Phenotypes
      • regulation of cell proliferation
      cerebral cortex Present
      Phenotypes
      • regulation of neuron differentiation
      endocardium Present
      hair follicle Present
      skin Present
      Reference