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Details for messenger / hormone: FGF-9

EndoNet ID: ENH00299

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Synonyms

  • fibroblast growth factor 9
  • FGF-9
  • FGF9
  • fibroblast growth factor-9
  • GAF
  • glia-activating factor
  • HBGF-9
  • heparin-binding growth factor 9

General information

  • Important for motoneuron survival and lung and testes development.
  • FGF-9 enhances cholinergic properties in forebrain cholinergic neurons via different but synergistical pathways. [1]
  • FGF-9 is involved in the neuropathology of Alzheimer's disease. [2]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • heparin-binding growth factors

      Composition

      Sequence
      LGEVGNYFG VQDAVPFGN VPVLPVDSP 
      VLLSDHLGQ SEAGGLPRG PAVTDLDHL 
      KGILRRRQL YCRTGFHLE IFPNGTIQG 
      TRKDHSRFG ILEFISIAV GLVSIRGVD 
      SGLYLGMNE KGELYGSEK LTQECVFRE 
      QFEENWYNT YSSNLYKHV DTGRRYYVA 
      LNKDGTPRE GTRTKRHQK FTHFLPRPV 
      DPDKVPELY KDILSQS

      Links to other resources

      UniProt P31371
      Ensembl ENST00000382353
      KEGG hsa:2254
      • Anatomical structure: endocardium

        • Here, we demonstrate specific expression of Fgf9, Fgf16, and Fgf20 in the epicardium and endocardium of the midgestation mouse heart. [3]
      • Anatomical structure: pericardium

        • Here, we demonstrate specific expression of Fgf9, Fgf16, and Fgf20 in the epicardium (inner layer of pericardium) and endocardium of the midgestation mouse heart. [3]

      Targets

      CellFGFR-1FGFR-2FGFR-3FGFR-4
      adrenal cortex Present
      Present
      brain Present
      Phenotypes
      • Kallmann syndrome 2
      • olfactory bulb morphogenesis
      cardiac muscle Present
      Phenotypes
      • regulation of cell proliferation
      Present
      Phenotypes
      • regulation of cell proliferation
      cerebral cortex Present
      Phenotypes
      • regulation of neuron differentiation
      chondrocyte Present
      Present
      Phenotypes
      • endochondral ossification
      endocardium Present
      hepatocyte Present
      Reference