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Details for messenger / hormone: FGF-19

EndoNet ID: ENH00304

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Synonyms

  • fibroblast growth factor 19
  • FGF-19
  • FGF19
  • fibroblast growth factor-19
  • FGFJ

General information

  • Binds selectively FGFR4. [1]
  • Expressed during embryogenesis and brain development.
  • FGF-19 and FGF-20 exert different effects on cell survival and cell locomotion. [2]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • heparin-binding growth factors

      Composition

      Sequence
      LAFSDAGPH VHYGWGDPI RLRHLYTSG 
      PHGLSSCFL RIRADGVVD CARGQSAHS 
      LLEIKAVAL RTVAIKGVH SVRYLCMGA 
      DGKMQGLLQ YSEEDCAFE EEIRPDGYN 
      VYRSEKHRL PVSLSSAKQ RQLYKNRGF 
      LPLSHFLPM LPMVPEEPE DLRGHLESD 
      MFSSPLETD SMDPFGLVT GLEAVRSPS 
      FEK

      Links to other resources

      UniProt O95750
      Ensembl ENST00000294312
      KEGG hsa:9965
      • Anatomical structure: hepatocyte

        Influenced by:

        • bile acid receptor
          in hepatocyte
          • FXR induces expression of FGF-19 in primary cultures of human hepatocytes. [3]

      Targets

      Reference