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Details for messenger / hormone: FGF-21

EndoNet ID: ENH00305

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Synonyms

  • fibroblast growth factor 21
  • FGF-21
  • FGF21
  • fibroblast growth factor-21
  • FGFL

General information

  • The FGF21-PPARalpha endocrine signaling pathway regulates various metabolic and behavioral aspects of the adaptive response to starvation. [1]
  • FGF-21 is a liver-derived endocrine factor that stimulates glucose uptake in adipocytes. [2]
  • FGF-21 is regulated by the peroxisome proliferator-activated receptor alpha (PPARalpha). [3]
  • FGF-21 is a critical regulator of lipid homeostasis and identify a physiological role for this hepatic hormone. [4]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • heparin-binding growth factors

      Composition

      Sequence
      HPIPDSSPL LQFGGQVRQ RYLYTDDAQ 
      QTEAHLEIR EDGTVGGAA DQSPESLLQ 
      LKALKPGVI QILGVKTSR FLCQRPDGA 
      LYGSLHFDP EACSFRELL LEDGYNVYQ 
      SEAHGLPLH LPGNKSPHR DPAPRGPAR 
      FLPLPGLPP ALPEPPGIL APQPPDVGS 
      SDPLSMVGP SQGRSPSYA S

      Links to other resources

      UniProt Q9NSA1
      Ensembl ENST00000222157
      KEGG hsa:26291
      • Anatomical structure: thymus

      Targets

      CellFGFR-1Klotho beta-like protein
      adrenal cortex Present
      brain Present
      Phenotypes
      • Kallmann syndrome 2
      • olfactory bulb morphogenesis
      cardiac muscle Present
      Phenotypes
      • regulation of cell proliferation
      chondrocyte Present
      Reference