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Details for messenger / hormone: M-CSF

EndoNet ID: ENH00306

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Synonyms

  • macrophage colony-stimulating factor 1
  • M-CSF
  • CSF-1
  • colony-stimulating factor 1
  • colony stimulating factor 1
  • CSF1
  • MCSF
  • macrophage colony stimulating factor-1
  • lanimostim

General information

  • M-CSF is required for proliferation, survival, and expression of receptor activator of nuclear factor kappa B (RANK) in osteoclast precursors. [1]
  • CSF-1 regulates the survival, proliferation, and differentiation of mononuclear phagocytes. [2]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines

    Composition

    macrophage colony-stimulating factor 1

    Sequence 
    EEVSEYCSH MIGSGHLQS LQRLIDSQM 
ETSCQITFE FVDQEQLKD PVCYLKKAF 
LLVQDIMED TMRFRDNTP NAIAIVQLQ 
ELSLRLKSC FTKDYEEHD KACVRTFYE 
TPLQLLEKV KNVFNETKN LLDKDWNIF 
SKNCNNSFA ECSSQDVVT KPDCNCLYP 
KAIPSSDPA SVSPHQPLA PSMAPVAGL 
TWEDSEGTE GSSLLPGEQ PLHTVDPGS 
AKQRPPRST CQSFEPPET PVVKDSTIG 
GSPQPRPSV GAFNPGMED ILDSAMGTN 
WVPEEASGE ASEIPVPQG TELSPSRPG 
GGSMQTEPA RPSNFLSAS SPLPASAKG 
QQPADVTGT ALPRVGPVR PTGQDWNHT 
PQKTDHPSA LLRDPPEPG SPRISSLRP 
QGLSNPSTL SAQPQLSRS HSSGSVLPL 
GELEGRRST RDRRSPAEP EGGPASEGA 
ARPLPRFNS VPLTDTGHE RQSEGSSSP 
QLQESVFHL LVPSVILVL LAVGGLLFY 
RWRRRSHQE PQRADSPLE QPEGSPLTQ 
DDRQVELPV
    UniProt P09603

    Links to other resources

    UniProt P09603
    Ensembl ENST00000369802
    KEGG hsa:1435

    • Anatomical structure: monocyte

    • Anatomical structure: continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

    • Anatomical structure: fibroblast

    • Anatomical structure: osteoblast

      • In vivo, CSF-1 synthesis by osteoblasts is temporally and spatially related to sites of osteoclast development. [3]

      Influenced by:

      • PTHR1
        in osteoblast
        • Stromal cells and osteoblasts express RANKL and M-CSF, which are up-regulated by osteoclastogenic molecules such as PTH. [4]

    • Anatomical structure: stromal_cell_of_bone_marrow

      • CSF-1 is expressed by stroma as a soluble glycoprotein, as proteoglycan, or as a membrane-spanning cs glycoprotein. [2]

      Influenced by:

      • PTHR1
        in stromal_cell_of_bone_marrow
        • Stromal cells and osteoblasts express RANKL and M-CSF, which are up-regulated by osteoclastogenic molecules such as PTH. [4]

    • Anatomical structure: osteoblast

    • Anatomical structure: hepatocyte

    Targets

    CellIGF-2RM-CSF-1-R
    adrenal cortex Present
    bone marrow Present
    Phenotypes
    • myeloid cell differentation
    hematopoietic stem cell Present
    monoblast Present
    monocyte Present
    osteoclast Present
    osteoclast Present
    Reference