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Details for messenger / hormone: SCF

EndoNet ID: ENH00307

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Synonyms

  • C-kit ligand
  • kit ligand
  • SCF
  • stem cell factor
  • MGF
  • mast cell growth factor

General information

  • Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins. [1]
  • Stem cell factor (SCF) is a newly described hematopoietic growth factor that stimulates the growth of primitive hematopoietic progenitors and mast cells. [2]
  • SCF works in concert with other factors produced by nonhematopoietic marrow cells to increase the precursor pool for osteoclasts and that other factors, such as 1,25-(OH)2D3, complete the differentiation process to the mature osteoclast. [2]

Classification

Hormone function

  • development and growth
    • growth stimulation
      • embryogenesis

      Chemical classification

      • hormone
        • genome-encoded
          • cytokines

      Composition

      Kit ligand

      Sequence 
      EGICRNRVT NNVKDVTKL VANLPKDYM 
ITLKYVPGM DVLPSHCWI SEMVVQLSD 
SLTDLLDKF SNISEGLSN YSIIDKLVN 
IVDDLVECV KENSSKDLK KSFKSPEPR 
LFTPEEFFR IFNRSIDAF KDFVVASET 
SDCVVSSTL SPEKDSRVS VTKPFMLPP 
VAASSLRND SSSSNRKAK NPPGDSSLH 
WAAMALPAL FSLIIGFAF GALYWKKRQ 
PSLTRAVEN IQINEEDNE ISMLQEKER 
EFQEV
      UniProt P21583

      Links to other resources

      UniProt P21583
      Ensembl ENST00000347404
      KEGG hsa:4254

      • Anatomical structure: hepatocyte

      Targets

      Reference