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Details for messenger / hormone: MK

EndoNet ID: ENH00308

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Synonyms

  • Midkine
  • MK
  • MDK
  • midkine (neurite growth-promoting factor 2)
  • NEGF2
  • midgestation and kidney protein
  • ARAP
  • amphiregulin-associated protein
  • neurite outgrowth-promoting factor 2
  • neurite outgrowth-promoting protein

General information

  • Midkine (MK) is a heparin-binding growth factor or cytokine that promotes growth, survival, differentiation, migration and other activities of target cells. [1]
  • MK is rich in both basic amino acids and cysteine, and has a molecular weight of around 13 kDa. Pleiotrophin (PTN), also called heparin-binding growth-associate molecule (HB-GAM), has about 50 % sequence identity to MK. However, the two are not closely related to other proteins. [1]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines

    Composition

    midkine

    Sequence
    VAKKKDKVK KGGPGSECA EWAWGPCTP 
    SSKDCGVGF REGTCGAQT QRIRCRVPC 
    NWKKEFGAD CKYKFENWG ACDGGTGTK 
    VRQGTLKKA RYNAQCQET IRVTKPCTP 
    KTKAKAKAK KGKGKD
    UniProt P21741

    Links to other resources

    UniProt P21741
    Ensembl ENST00000407067
    KEGG hsa:4192

      Targets

      CellPTPRB
      central nerve system element Present
      Phenotypes
      • neuronal migration
      Reference