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Details for messenger / hormone: PTN

EndoNet ID: ENH00309

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Synonyms

  • HB-GAM
  • heparin-binding neurite outgrowth-promoting factor 1
  • PTN
  • pleiotrophin
  • HBGF-8
  • heparin-binding growth factor 8
  • OSF-1
  • osteoblast-specific factor 1
  • HBNF-1
  • heparin-binding neurite outgrowth promoting factor 1
  • HBBM
  • heparin-binding brain mitogen
  • heparin-binding growth-associated molecule

General information

  • OSF is a novel intracellular protein that indirectly enhances osteoclast formation and osteoclastic bone resorption through the cellular signal transduction cascade, possibly through its interactions with c-Src or other Src-related proteins. [1]
  • Pleiotrophin (PTN) is an 18 kDa heparin-binding cytokine and shares 50% sequence homology with midkine. PTN has two beta-sheet domains that bind to heparin and extracellular matrix with high affinity. The amino acid sequence of PTN is highly conserved among different organisms. [2]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines

    Composition

    Sequence
    GKKEKPEKK VKKSDCGEW QWSVCVPTS 
    GDCGLGTRE GTRTGAECK QTMKTQRCK 
    IPCNWKKQF GAECKYQFQ AWGECDLNT 
    ALKTRTGSL KRALHNAEC QKTVTISKP 
    CGKLTKPKP QAESKKKKK EGKKQEKML 
    D
    UniProt P21246

    Links to other resources

    UniProt P21246
    Ensembl ENST00000348225
    KEGG hsa:5764
    • Anatomical structure: central_nerve_system_element

      • During mouse embryogenesis, PTN is highly expressed in the central and peripheral nervous systems, in organs undergoing branching morphogenesis including the salivary glands, lung and kidney, digestive and skeletal systems, sense organs and facial processes, and limbs. [2]
      • In the adult stage, PTN expression is mainly restricted to the central nervous system. [2]

    Targets

    CellAnaplastic lymphoma kinasePTPRBSyndecan-3
    central nerve system element Present
    Phenotypes
    • neuronal migration
    neuron Present
    Phenotypes
    • neurite elongation
    Reference