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Details for messenger / hormone: EPR

EndoNet ID: ENH00316

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Synonyms

  • EREG
  • Proepiregulin
  • EPR
  • epiregulin
  • ER

General information

  • Amphiregulin and epiregulin belong to the epidermal growth factor family, and act as mitogenic stimulators via binding to EGF receptors. [1]
  • Epiregulin as a major autocrine/paracrine factor released from ERK- and p38MAPK-activated vascular smooth muscle cells. [2]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines

    Composition

    Epiregulin mature peptide

    Sequence
    MTAGRRMEM LCAGRVPAL LLCLGFHLL 
    QAVLSTTVI PSCIPGESS DNCTALVQT 
    EDNPRVAQV SITKCSSDM NGYCLHGQC 
    IYLVDMSQN YCRCEVGYT GVRCEHFFL 
    TVHQPLSKE YVALTVILI ILFLITVVG 
    STYYFCRWY RNRKSKEPK KEYERVTSG 
    DPELPQV

    Links to other resources

    UniProt O14944
    Ensembl ENST00000244869
    KEGG hsa:2069

      Targets

      CellADAM17EGFR isoform aErbB4
      astrocyte Present
      brain Present
      cerebellar cortex Present
      cerebral cortex Present
      continuous vascular endothelial cell of blood vessels and lymphatics Present
      Phenotypes
      • regulation of angiogenesis
      digestive system Present
      epithelial cell Present
      epithelial cell with microvilli Present
      Influences
      • mucin-2
      G cell Present
      Influences
      • gastrin
      hepatocyte Present
      Influences
      • IL-1 alpha
      • IL-1 beta
      hippocampus Present
      keratinocyte Present
      lipocyte of liver Present
      Phenotypes
      • positive regulation of cell proliferation and apotosis
      lung Present
      macrophage Present
      monocyte Present
      Phenotypes
      • ectodomain shedding
      neuron Present
      neutrophil granulocyte Present
      Phenotypes
      • ectodomain shedding
      Present
      Influences
      • IL-8
      placenta Present
      T-lymphocyte Present
      Phenotypes
      • ectodomain shedding
      uterus Present
      Reference