Status
Please wait ...

Details for messenger / hormone: CLC

EndoNet ID: ENH00320

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • CLC
  • B-cell-stimulating factor 3
  • cardiotrophin-like cytokine
  • B-cell stimulatory factor 3
  • BSF3
  • B cell-stimulating factor 3
  • BSF-3
  • novel neurotrophin-1
  • NNT1
  • NNT-1
  • cardiotrophin-like cytokine factor 1

General information

  • Belongs to the interleukin-6 family of cytokines, which are involved in cell signaling through phosphorylation of gp130. [1]
  • NNT-1/BSF-3 is a gp130 activator with B-cell stimulating capability. [2]
  • Cellular secretion of NNT-1/BSF-3 requires heteromeric complex formation with other factors, e.g. cytokine-like factor-1 (CLF-1) or soluble ciliary neurotrophic factor receptor (sCNTFR). [3]
  • BSF-3 is a novel myeloma growth and survival factor with a potential role in the pathophysiology of the disease. [4]
  • Cardiotrophin-like cytokine/cytokine-like factor 1 is an essential trophic factor for lumbar and facial motoneurons in vivo. [5]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • IL-6-type cytokines

      Composition

      Sequence 
      LNRTGDPGP GPSIQKTYD LTRYLEHQL 
RSLAGTYLN YLGPPFNEP DFNPPRLGA 
ETLPRATVD LEVWRSLND KLRLTQNYE 
AYSHLLCYL RGLNRQAAT AELRRSLAH 
FCTSLQGLL GSIAGVMAA LGYPLPQPL 
PGTEPTWTP GPAHSDFLQ KMDDFWLLK 
ELQTWLWRS AKDFNRLKK KMQPPAAAV 
TLHLGAHGF

      Links to other resources

      UniProt Q9UBD9
      Ensembl ENST00000312438

      • Anatomical structure: spleen

      • Anatomical structure: lymphocyte

      • Anatomical structure: bone_marrow

      • Anatomical structure: continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

      • Anatomical structure: brain

      Targets

      CellCNTFRIL6STLIFR
      cell of endometrium of uterus Present
      		Present
      hypothalamus Present
      Phenotypes
      • positive regulation of neurogenesis
      Reference